{"id":"W3164191983","doi":"10.1146/annurev-genom-121420-081805","title":"Avoiding Extinction: Recent Advances in Understanding Mechanisms of Mitochondrial DNA Purifying Selection in the Germline","year":2021,"lang":"en","type":"review","venue":"Annual Review of Genomics and Human Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; University of Toronto","keywords":"Mitochondrial DNA; Biology; Germline; Multicellular organism; Genome; Negative selection; Genetics; Evolutionary biology; Mitochondrion; Genomics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008872675,0.0009348882,0.001444959,0.001741388,0.0004084732,0.001522852,0.001232188,0.001685315,0.002782525],"category_scores_gemma":[0.001017722,0.0003206118,0.0004515518,0.001647276,0.00109532,0.003074633,0.001113846,0.002186916,0.001759694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009329022,"about_ca_system_score_gemma":0.001316246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036244,"about_ca_topic_score_gemma":0.001230946,"domain_scores_codex":[0.999819,0.00002912665,0.00002178113,0.0000509081,0.00005481727,0.00002437562],"domain_scores_gemma":[0.9994472,0.0003023355,0.00006448251,0.00001817925,0.0001037165,0.00006413062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007698024,0.00003999396,0.0002467685,0.01964587,0.00008725333,0.0002730629,0.000148903,0.000700736,0.004807321,0.01840129,0.01664573,0.9389261],"study_design_scores_gemma":[0.000009601626,0.00008411262,0.0007701399,0.002659545,0.0000898924,0.000788938,0.0001098548,0.0001682701,0.001185545,0.009750385,0.9843475,0.00003631607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001244597,0.9982221,0.0003365951,0.0004158526,0.0001649193,0.000002251641,0.00001146227,0.00001102522,0.000711425],"genre_scores_gemma":[0.0006843692,0.9983969,0.0002602389,0.0001839928,0.0001735954,0.000004264205,0.00001978539,0.000002461886,0.0002743216],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002782525,"threshold_uncertainty_score":0.009308457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04798244166914849,"score_gpt":0.3354146381217911,"score_spread":0.2874321964526426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}