{"id":"W3164197617","doi":"10.1038/s41593-021-00859-9","title":"Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway","year":2021,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute on Aging; ALS Association; Muscular Dystrophy Association; Johns Hopkins University; Human Frontier Science Program; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Nucleoporin; Nuclear pore; Neurodegeneration; Cell biology; Biology; Cytoplasm; Nuclear transport; Mutant; Phenotype; Nucleus; Cell nucleus; Chemistry; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908705,0.00009777869,0.0001012218,0.00003708533,0.0001474648,0.00004700428,0.0002038877,0.0001156608,0.000002017393],"category_scores_gemma":[0.000379956,0.00006818095,0.0000326125,0.0003651686,0.0001077877,0.00001133597,0.00004061354,0.0005146217,5.474543e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001086652,"about_ca_system_score_gemma":0.000099819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007249183,"about_ca_topic_score_gemma":0.0007700687,"domain_scores_codex":[0.9989733,0.00009613038,0.00009538834,0.000360838,0.0002276474,0.0002466629],"domain_scores_gemma":[0.9995561,0.00005525182,0.00004729624,0.0002122962,0.00006220533,0.00006690311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001987576,0.00005469245,0.179647,0.000005855041,0.000003959984,0.0001676472,0.00006366471,0.00001819623,0.8195398,0.0000381375,0.00007647106,0.000364625],"study_design_scores_gemma":[0.000385666,0.0001617866,0.9300062,0.00003405418,0.000006899556,0.00005974854,0.0001646271,0.00006797401,0.06419391,0.00001721055,0.004787151,0.0001147784],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986914,0.0001477548,0.00003539688,0.000506617,0.0000761332,0.0001067549,0.0000254915,0.000008246619,0.0004021579],"genre_scores_gemma":[0.9984838,0.00006474786,0.00002154095,0.001044912,0.00004533356,0.000007013333,0.00002336812,0.000008946528,0.0003003056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7553459,"threshold_uncertainty_score":0.2780339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471427598434307,"score_gpt":0.272594089123767,"score_spread":0.257879813139424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}