{"id":"W3164197617","doi":"10.1038/s41593-021-00859-9","title":"Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway","year":2021,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute on Aging; ALS Association; Muscular Dystrophy Association; Johns Hopkins University; Human Frontier Science Program; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Nucleoporin; Nuclear pore; Neurodegeneration; Cell biology; Biology; Cytoplasm; Nuclear transport; Mutant; Phenotype; Nucleus; Cell nucleus; Chemistry; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004099266,0.0008129269,0.000525408,0.0008408188,0.0007403779,0.0005956099,0.0004872038,0.001394465,0.002097408],"category_scores_gemma":[0.0006875654,0.0003205142,0.0005003101,0.0004770333,0.001034264,0.0004880916,0.0008518087,0.001056693,0.0006224254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006453678,"about_ca_system_score_gemma":0.000337601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123321,"about_ca_topic_score_gemma":0.001156182,"domain_scores_codex":[0.9994294,0.0001340748,0.0000912758,0.00009726382,0.0001730448,0.00007497946],"domain_scores_gemma":[0.9987515,0.0002908857,0.0005718494,0.00008901981,0.00007010653,0.0002266406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005830585,0.00007070479,0.001617193,0.00003385969,0.00008727988,0.00390404,0.00007362162,0.0006707588,0.9900084,0.001182259,0.0002933893,0.001475479],"study_design_scores_gemma":[0.0001631647,0.0002982902,0.04120407,0.00003458457,0.0002009212,0.02995925,0.0003578165,0.01253439,0.9075666,0.002770478,0.004830922,0.00007959614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954107,0.000420271,0.002689356,0.0001962639,0.00004015361,0.00001118422,0.0002325069,0.00008649316,0.0009130716],"genre_scores_gemma":[0.9982317,0.0001059868,0.0007982456,0.000054,0.00001574153,0.000008364461,0.0001599133,0.0000332474,0.0005928911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002097408,"threshold_uncertainty_score":0.00701648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471427598434307,"score_gpt":0.272594089123767,"score_spread":0.257879813139424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}