{"id":"W3164200337","doi":"10.1007/s40263-021-00814-z","title":"Effect of a Multi-Layer, Extended-Release Methylphenidate Formulation (PRC-063) on Sleep in Adults with ADHD: A Randomized, Double-Blind, Forced-Dose, Placebo-Controlled Trial Followed by a 6-month Open-Label Extension","year":2021,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); University of Alberta","funders":"Purdue Pharma; Purdue University","keywords":"Pittsburgh Sleep Quality Index; Methylphenidate; Placebo; Stimulant; Clinical trial; Medicine; Adverse effect; Randomized controlled trial; Open label; Attention deficit hyperactivity disorder; Insomnia; Internal medicine; Anesthesia; Psychiatry; Sleep quality","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001555636,0.001471799,0.002655809,0.0005118821,0.0004872432,0.0007301244,0.001566557,0.001750602,0.004413008],"category_scores_gemma":[0.001198062,0.0007949432,0.001746844,0.0004325501,0.0009580471,0.001022117,0.0004732372,0.002564953,0.0008677994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00071492,"about_ca_system_score_gemma":0.001413962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001956678,"about_ca_topic_score_gemma":0.005278451,"domain_scores_codex":[0.9995289,0.0001838025,0.0000558042,0.0001003633,0.00005755514,0.00007369817],"domain_scores_gemma":[0.9992352,0.0001741482,0.0001667875,0.00007688592,0.00008014689,0.0002669423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9580463,0.01508583,0.0004942586,0.0006401072,0.0004659911,0.00003512955,0.00006252034,0.0001772695,0.005355529,0.00004459826,0.0003002462,0.0192923],"study_design_scores_gemma":[0.885765,0.110437,0.00210673,0.00002428095,0.0002439511,0.00003282679,0.00002184026,0.0002901554,0.0008271529,0.00002452767,0.0002123693,0.00001420013],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992249,0.002579876,0.000364384,0.0002123575,0.0002414507,0.002942705,0.0005994839,0.0001251865,0.0006855337],"genre_scores_gemma":[0.9882067,0.002754319,0.002526437,0.0004363127,0.0003099817,0.003004777,0.0008675074,0.0000251285,0.001868985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004413008,"threshold_uncertainty_score":0.014763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0375773965351871,"score_gpt":0.3543715755283068,"score_spread":0.3167941789931197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}