{"id":"W3164200337","doi":"10.1007/s40263-021-00814-z","title":"Effect of a Multi-Layer, Extended-Release Methylphenidate Formulation (PRC-063) on Sleep in Adults with ADHD: A Randomized, Double-Blind, Forced-Dose, Placebo-Controlled Trial Followed by a 6-month Open-Label Extension","year":2021,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); University of Alberta","funders":"Purdue Pharma; Purdue University","keywords":"Pittsburgh Sleep Quality Index; Methylphenidate; Placebo; Stimulant; Clinical trial; Medicine; Adverse effect; Randomized controlled trial; Open label; Attention deficit hyperactivity disorder; Insomnia; Internal medicine; Anesthesia; Psychiatry; Sleep quality","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002760554,0.0006389617,0.003001717,0.0004382562,0.0001390944,0.00008984185,0.0002631982,0.0003279402,0.0001456232],"category_scores_gemma":[0.002102836,0.0004643156,0.0004877005,0.0008242611,0.00009954494,0.0005311949,0.0001651286,0.000600352,0.00004251473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881233,"about_ca_system_score_gemma":0.0003016912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000364646,"about_ca_topic_score_gemma":0.0001962804,"domain_scores_codex":[0.9947973,0.001300188,0.001301833,0.001048497,0.0009681711,0.0005839331],"domain_scores_gemma":[0.9953707,0.002182828,0.0007769453,0.0009335214,0.0004662334,0.0002697205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9742376,0.004555111,0.00004762378,0.0002464932,0.0005773551,0.000122499,0.001009849,0.0003752102,0.0107619,0.00006404341,0.0001879553,0.007814392],"study_design_scores_gemma":[0.9317955,0.003630749,0.00002441945,0.0009019422,0.001269755,0.00002550874,0.0007895331,0.05460058,0.006486092,0.00001479112,0.00003530883,0.000425823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974088,0.0008606439,0.001714588,0.000555428,0.0003078896,0.02150765,0.00002282608,0.00008994453,0.0008530574],"genre_scores_gemma":[0.992534,0.00005783894,0.000960657,0.0002038171,0.00008224833,0.003309772,0.0003961772,0.0001161258,0.002339388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05422537,"threshold_uncertainty_score":0.9997808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0375773965351871,"score_gpt":0.3543715755283068,"score_spread":0.3167941789931197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}