{"id":"W3164212230","doi":"10.3390/cancers13112605","title":"Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Triple-negative breast cancer; Biology; Estrogen receptor; Endocrinology; Cholesterol; Internal medicine; Pentose phosphate pathway; Cancer research; Breast cancer; Chemistry; Cancer; Medicine; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008850811,0.0002351188,0.0002683705,0.0002885179,0.0001675215,0.0003675475,0.0001078148,0.0001531806,0.001163503],"category_scores_gemma":[0.0001098868,0.0001000777,0.0002456012,0.0003854412,0.0001354422,0.0001243456,0.0002168554,0.0002937963,0.0005897782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070622,"about_ca_system_score_gemma":0.0001998057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008278465,"about_ca_topic_score_gemma":0.001319145,"domain_scores_codex":[0.9998654,0.00002223596,0.00001303753,0.0000313583,0.00004070166,0.00002728684],"domain_scores_gemma":[0.9999274,0.00001027483,0.00002128412,0.00001551039,0.00001598248,0.000009453293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002541498,0.00002174135,0.001008412,0.00007492033,0.00001005653,0.0001737477,0.00001865412,0.00008990868,0.9939447,0.0001632511,0.0001192198,0.004121265],"study_design_scores_gemma":[0.0000289333,0.0002147625,0.02666804,0.00001903355,0.0000392016,0.0009704696,0.0001098205,0.0006903503,0.9612563,0.0002388154,0.00975025,0.00001415159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767556,0.008484236,0.005804274,0.000492827,0.0001171966,0.00003454344,0.003215047,0.0002569403,0.00483938],"genre_scores_gemma":[0.9867513,0.004618031,0.002606103,0.0001606563,0.00001829321,0.00002834051,0.002446377,0.00002273082,0.003348141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163503,"threshold_uncertainty_score":0.003892362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113484521982516,"score_gpt":0.2496799703818031,"score_spread":0.238545125161978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}