{"id":"W3164212230","doi":"10.3390/cancers13112605","title":"Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Triple-negative breast cancer; Biology; Estrogen receptor; Endocrinology; Cholesterol; Internal medicine; Pentose phosphate pathway; Cancer research; Breast cancer; Chemistry; Cancer; Medicine; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618811,0.0002235807,0.0002753431,0.00004113964,0.00008808672,0.00004577421,0.0002538143,0.0001733831,0.000139551],"category_scores_gemma":[0.00002137292,0.0001853368,0.0001461943,0.0003203631,0.00008714592,0.000008400374,0.0001049845,0.0002071098,0.00001118324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415186,"about_ca_system_score_gemma":0.001016562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002632486,"about_ca_topic_score_gemma":0.003586732,"domain_scores_codex":[0.9984068,0.0000972515,0.000276368,0.0005850301,0.0001867883,0.0004477127],"domain_scores_gemma":[0.9989982,0.00001210769,0.0001117677,0.0006251123,0.0001258755,0.0001269297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004509143,0.00001804967,0.001228368,0.00001676881,0.0000891446,8.318658e-7,0.0003800397,0.0001377967,0.9454811,0.00001048455,0.008862789,0.0437296],"study_design_scores_gemma":[0.0007263182,0.00001355257,0.006332542,0.00002211599,0.00003233078,0.00001619415,0.0002580641,0.00004980587,0.3710849,0.000005950832,0.6212488,0.0002094555],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695942,0.01763438,0.00007442613,0.001584409,0.009981941,0.0003288848,0.0002158164,0.00002716099,0.0005587503],"genre_scores_gemma":[0.9731647,0.01112748,0.00006398497,0.005276139,0.009013616,0.0002813136,0.00008881124,0.00006182851,0.0009220768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.612386,"threshold_uncertainty_score":0.7557815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113484521982516,"score_gpt":0.2496799703818031,"score_spread":0.238545125161978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}