{"id":"W3164216879","doi":"10.1021/acs.analchem.1c01125","title":"Lipid Droplet-Specific Fluorescent Probe for <i>In Vivo</i> Visualization of Polarity in Fatty Liver, Inflammation, and Cancer Models","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Shanxi Province Hundred Talents Project; National Natural Science Foundation of China","keywords":"Chemistry; Polarity (international relations); Fluorescence; Cancer; In vivo; Biophysics; Pyridinium; Nile red; Biochemistry; Cell; Medicine; Biology; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401316,0.0001123317,0.0002000845,0.00002004985,0.00002145471,0.00001442272,0.000075716,0.0001723503,0.00003144381],"category_scores_gemma":[0.00009762195,0.0001115833,0.00005501123,0.0001325588,0.00005759825,0.00000838025,0.00006765759,0.00005457493,1.897678e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001847085,"about_ca_system_score_gemma":0.0001065262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000257308,"about_ca_topic_score_gemma":0.00006168446,"domain_scores_codex":[0.9990938,0.00002297467,0.0002951674,0.0003139655,0.0001042942,0.0001698383],"domain_scores_gemma":[0.9995452,0.0000190139,0.00006028381,0.0001810654,0.0001355809,0.00005886417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006129516,0.0001138344,0.00609544,0.000265072,0.00001680517,0.000001572183,0.0000377075,0.00003801335,0.9915206,0.0003768237,0.0001329691,0.001339911],"study_design_scores_gemma":[0.0004888347,0.000008594136,0.001331031,0.00004623178,0.00001839867,0.000001733911,0.00003128789,0.003353508,0.9863542,0.00009031668,0.0081469,0.000129016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924293,0.002673256,0.004197432,0.0001197413,0.00002949822,0.0001533885,0.00005737877,0.000004902443,0.000335143],"genre_scores_gemma":[0.9965727,0.00211852,0.0006936294,0.00004190458,0.0002534413,0.00002572059,0.0001067771,0.00001219431,0.0001751112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008013931,"threshold_uncertainty_score":0.4550236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595473524266664,"score_gpt":0.2585409388736934,"score_spread":0.2425862036310268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}