{"id":"W3164216879","doi":"10.1021/acs.analchem.1c01125","title":"Lipid Droplet-Specific Fluorescent Probe for <i>In Vivo</i> Visualization of Polarity in Fatty Liver, Inflammation, and Cancer Models","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Shanxi Province Hundred Talents Project; National Natural Science Foundation of China","keywords":"Chemistry; Polarity (international relations); Fluorescence; Cancer; In vivo; Biophysics; Pyridinium; Nile red; Biochemistry; Cell; Medicine; Biology; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002966212,0.0004386231,0.0001756219,0.0002646453,0.0001993815,0.0002204999,0.0003043613,0.0006080727,0.0009066383],"category_scores_gemma":[0.0002285073,0.000170945,0.00021183,0.0002085138,0.0002655129,0.0004757144,0.0003450332,0.0005630457,0.0003978707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335181,"about_ca_system_score_gemma":0.0002311606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004135145,"about_ca_topic_score_gemma":0.0005218934,"domain_scores_codex":[0.9998639,0.00003859821,0.000006727787,0.00004098137,0.0000240541,0.00002573854],"domain_scores_gemma":[0.9999188,0.00001927918,0.00002498207,0.000009284084,0.00001427565,0.00001331511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002203527,0.000005426672,0.0000296083,0.00003403701,0.000001402975,0.00003362459,0.000007988133,0.00004481935,0.9985327,0.00020486,0.00007284549,0.001010664],"study_design_scores_gemma":[0.000006398502,0.00006403145,0.0002969805,0.000003636943,0.000003965656,0.0001544487,0.000008423091,0.001043039,0.9965854,0.00008349388,0.001745177,0.000005087397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7520504,0.005973654,0.2285424,0.0009615325,0.0001569823,0.0002191454,0.0006940542,0.0007923506,0.01060956],"genre_scores_gemma":[0.9146136,0.004019392,0.0755479,0.0005016347,0.00004274134,0.0003047746,0.0005752778,0.00009725384,0.004297391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009066383,"threshold_uncertainty_score":0.003033042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595473524266664,"score_gpt":0.2585409388736934,"score_spread":0.2425862036310268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}