{"id":"W3164234380","doi":"10.1136/annrheumdis-2021-eular.359","title":"POS0652 SEX DIFFERENCES IN THE EFFICACY AND SAFETY OF TOFACITINIB IN RHEUMATOID ARTHRITIS PATIENTS: A POST HOC ANALYSIS OF PHASE 3 AND LONG-TERM EXTENSION TRIALS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital; University of Toronto; Pfizer (Canada); University of Alberta","funders":"Pfizer","keywords":"Tofacitinib; Medicine; Rheumatoid arthritis; Janus kinase inhibitor; Internal medicine; Discontinuation; Adalimumab; Post-hoc analysis; Placebo; Clinical trial; Methotrexate; Surgery; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008586176,0.001628223,0.003823232,0.0004010256,0.0005044465,0.001769328,0.0007564952,0.001448789,0.006096602],"category_scores_gemma":[0.005935417,0.000642794,0.007705675,0.0005326589,0.001037239,0.001593882,0.0006655177,0.003081485,0.0007631403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005581981,"about_ca_system_score_gemma":0.0008324288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003367327,"about_ca_topic_score_gemma":0.000665448,"domain_scores_codex":[0.9943521,0.003887282,0.0003203401,0.0006850883,0.0003108146,0.0004444848],"domain_scores_gemma":[0.9946769,0.003004757,0.0008674306,0.0007021844,0.0003077223,0.0004410517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9698921,0.000678942,0.004382319,0.0002873662,0.01134019,0.00005893968,0.00004516869,0.0005110666,0.002581892,0.00008224476,0.0003766447,0.009763079],"study_design_scores_gemma":[0.4940691,0.3209136,0.1325431,0.0001751607,0.03977468,0.0004221656,0.0002424499,0.0029627,0.003916781,0.0009991573,0.003771433,0.0002097459],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889466,0.006357078,0.0007158529,0.0002417911,0.0003696753,0.0004498408,0.001270655,0.00006125231,0.00158735],"genre_scores_gemma":[0.9952806,0.001049947,0.0005169322,0.0003597577,0.0002232229,0.0003830178,0.000847445,0.00003184646,0.001307371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008586176,"threshold_uncertainty_score":0.04540861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06071091670102527,"score_gpt":0.3499488817582679,"score_spread":0.2892379650572426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}