{"id":"W3164242364","doi":"10.1038/s41467-021-22952-0","title":"Actuation enhances patterning in human neural tube organoids","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Interreg; Vlaamse regering; Koning Boudewijnstichting; KU Leuven; Fonds Wetenschappelijk Onderzoek","keywords":"Organoid; Neural tube; Tube (container); Cell biology; Nanotechnology; Materials science; Biology; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602986,0.0001992441,0.0001514394,0.0001474598,0.000109321,0.0002493095,0.0001180427,0.0001968559,0.001018361],"category_scores_gemma":[0.0001841988,0.0001207321,0.0001360468,0.00006816536,0.0001865275,0.0001403585,0.0003305861,0.0002001674,0.0002657763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957491,"about_ca_system_score_gemma":0.0001337316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003390311,"about_ca_topic_score_gemma":0.0007057203,"domain_scores_codex":[0.9998894,0.00001561449,0.000009631612,0.00003186598,0.00003733057,0.00001617744],"domain_scores_gemma":[0.999904,0.00003468385,0.0000217188,0.00001068676,0.000008955813,0.00001997166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001422216,0.000003817447,0.00004743082,0.00001375014,0.000001074987,0.00002481954,0.00001611204,0.0002130963,0.9987444,0.00006790977,0.00002466922,0.0008287271],"study_design_scores_gemma":[0.000006934104,0.0001236197,0.001573527,0.000005062374,0.000004032668,0.00009777699,0.00002571614,0.001591841,0.9940414,0.00006243158,0.002463081,0.000004418999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824959,0.001069666,0.01190021,0.0001271471,0.00005789366,0.00003926849,0.0002298909,0.00009637958,0.003983642],"genre_scores_gemma":[0.9929564,0.0003555601,0.004394605,0.00005578187,0.000006270095,0.00002726453,0.0001252575,0.00002546312,0.002053405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018361,"threshold_uncertainty_score":0.003406823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055880451043603,"score_gpt":0.3348729274851679,"score_spread":0.3143141229747319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}