{"id":"W3164270512","doi":"10.21203/rs.3.rs-622329/v1","title":"Transcriptional reprogramming of skeletal muscle stem cells by the niche environment","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Ottawa; McGill Genome Centre; Ottawa Hospital; McGill University","funders":"Lady Davis Institute for Medical Research; Jewish General Hospital","keywords":"Reprogramming; Niche; Skeletal muscle; Cell biology; Stem cell; Biology; Stem cell niche; Myocyte; Anatomy; Genetics; Ecology; Cell; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562683,0.0001962869,0.0001925595,0.0001327673,0.00008926273,0.0002841127,0.0001083312,0.0001282791,0.001173089],"category_scores_gemma":[0.0001625557,0.0001032436,0.0002403288,0.0001714854,0.0001603845,0.000153022,0.000287039,0.0002172132,0.0003444338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674902,"about_ca_system_score_gemma":0.0001524978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111887,"about_ca_topic_score_gemma":0.0004764248,"domain_scores_codex":[0.9999254,0.00001017894,0.000002970064,0.0000244146,0.00002467861,0.00001233404],"domain_scores_gemma":[0.9999418,0.0000177368,0.00001435892,0.00001031842,0.000007194342,0.000008670455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005188022,0.000009150401,0.001177471,0.00006606762,0.00001055095,0.00003735402,0.00001541818,0.001860334,0.9909209,0.0004811977,0.0001400046,0.005229665],"study_design_scores_gemma":[0.00001905328,0.0001426337,0.03790389,0.00002505231,0.00003254652,0.0002391686,0.00007568447,0.04977087,0.8980867,0.002889471,0.01079638,0.00001866574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329799,0.00187632,0.0589097,0.0001531251,0.0001048897,0.0000192129,0.002482523,0.0005708958,0.002903424],"genre_scores_gemma":[0.9698244,0.001011905,0.02293417,0.00008632033,0.00002849014,0.00002345838,0.002532656,0.0001687664,0.003389905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173089,"threshold_uncertainty_score":0.00392437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380626745954277,"score_gpt":0.318145737413024,"score_spread":0.2843394699534812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}