{"id":"W3164290369","doi":"10.3390/antibiotics10060620","title":"Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Alkylation; Chemistry; Prenylation; Moiety; Combinatorial chemistry; Antimicrobial; Organic chemistry; Catalysis; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243141,0.0001734247,0.0002453965,0.00003364445,0.00006009183,0.00002428881,0.00008405762,0.0003784599,0.00002392747],"category_scores_gemma":[0.000236403,0.0001533964,0.00005089591,0.0001260318,0.000182736,0.000005535272,0.000175372,0.0001178534,0.000001338255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001030921,"about_ca_system_score_gemma":0.00004505863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003922363,"about_ca_topic_score_gemma":0.00004831764,"domain_scores_codex":[0.9988186,0.0002013022,0.0002336503,0.0004176477,0.0001674811,0.000161317],"domain_scores_gemma":[0.9992086,0.00006609549,0.0001245051,0.0002579109,0.0002761096,0.00006672666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009539509,0.00007271366,0.0318277,0.00001717151,0.0001733814,0.000002714044,0.00006023869,0.000009037836,0.9581411,0.00001751828,0.00004523641,0.009537775],"study_design_scores_gemma":[0.0007409774,0.0001697598,0.04740476,0.00004990484,0.0001503482,0.00002362986,0.0001020911,0.00203395,0.9485059,0.0002720555,0.0003477771,0.0001988384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925082,0.006668016,0.00004187643,0.0001426378,0.00005793601,0.0001578045,0.00006179264,0.00001415234,0.0003475249],"genre_scores_gemma":[0.9976432,0.001346443,0.0004875401,0.00006059551,0.00004905392,4.616958e-7,0.0003564112,0.00001526147,0.00004098952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01557706,"threshold_uncertainty_score":0.6255323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591392716272535,"score_gpt":0.2776324467586344,"score_spread":0.251718519595909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}