{"id":"W3164290369","doi":"10.3390/antibiotics10060620","title":"Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Alkylation; Chemistry; Prenylation; Moiety; Combinatorial chemistry; Antimicrobial; Organic chemistry; Catalysis; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070908,0.0002430432,0.000119875,0.0001346023,0.00006420287,0.0001110416,0.0001167931,0.0001414421,0.0008549609],"category_scores_gemma":[0.0001080343,0.00005154991,0.00009825481,0.0001731785,0.0001372002,0.0001532372,0.00008851993,0.0002490169,0.0001590596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641806,"about_ca_system_score_gemma":0.0001874244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006191836,"about_ca_topic_score_gemma":0.001401524,"domain_scores_codex":[0.9999455,0.000008396522,0.000005658915,0.000009692564,0.00001903509,0.00001174734],"domain_scores_gemma":[0.9999039,0.00001781538,0.00002392808,0.00001488308,0.0000214338,0.00001801337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004083814,0.00001186366,0.00003308627,0.00001725953,0.000001387552,0.00002579344,0.000006826815,0.00006927642,0.999065,0.00003191206,0.00000452522,0.0006922666],"study_design_scores_gemma":[0.000005186496,0.000288245,0.000742376,0.000001732731,0.000005080513,0.000046565,0.000006648107,0.0001042908,0.9982511,0.00000838471,0.000538239,0.000001982378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959106,0.0008221279,0.001542562,0.00001541342,0.000007591802,0.00003416221,0.0003065207,0.00002760131,0.001333404],"genre_scores_gemma":[0.9960985,0.0006515876,0.001540237,0.00001168686,0.000003083125,0.00001888906,0.0003852322,0.000009783139,0.001280999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008549609,"threshold_uncertainty_score":0.002860129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591392716272535,"score_gpt":0.2776324467586344,"score_spread":0.251718519595909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}