{"id":"W3164307722","doi":"10.1053/j.ajkd.2021.05.005","title":"Canagliflozin and Kidney-Related Adverse Events in Type 2 Diabetes and CKD: Findings From the Randomized CREDENCE Trial","year":2021,"lang":"en","type":"article","venue":"American Journal of Kidney Diseases","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Research and Development; National Health and Medical Research Council; Medical Research Council; Novo Nordisk; Daiichi Sankyo Europe; Kidney Foundation of Canada; Gilead Sciences; Servier; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Pfizer; ZOLL Medical Corporation; Eli Lilly and Company; AstraZeneca; University of Washington; GlaxoSmithKline","keywords":"Medicine; Canagliflozin; Credence; Type 2 diabetes; Randomized controlled trial; Kidney disease; Adverse effect; Diabetes mellitus; Internal medicine; Intensive care medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0187952,0.001254266,0.002689382,0.0004934968,0.0004828108,0.001944726,0.001200879,0.002293692,0.005661422],"category_scores_gemma":[0.02724048,0.0004876812,0.003525049,0.0009414339,0.001809151,0.001225322,0.000780363,0.002342078,0.0005322496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005481803,"about_ca_system_score_gemma":0.001416779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008450284,"about_ca_topic_score_gemma":0.001203637,"domain_scores_codex":[0.986392,0.01067468,0.00081013,0.0007181428,0.001060403,0.0003445521],"domain_scores_gemma":[0.986492,0.007745788,0.003048408,0.001138554,0.0006596848,0.0009155039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9456123,0.002411885,0.006370243,0.0050021,0.008143253,0.00006886439,0.00007091749,0.0005615528,0.0005758886,0.0007189397,0.002959013,0.0275051],"study_design_scores_gemma":[0.9615563,0.01694845,0.008652772,0.0005686224,0.007351118,0.00009689396,0.00003466296,0.000492796,0.0002529126,0.0008670085,0.003149741,0.00002888641],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7872291,0.1468816,0.004272808,0.01252372,0.005230593,0.01749152,0.006513902,0.000265773,0.01959103],"genre_scores_gemma":[0.9584442,0.01610891,0.004336235,0.004682086,0.004640859,0.007149859,0.002568837,0.00003882759,0.002030261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0187952,"threshold_uncertainty_score":0.09939975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006211430291258336,"score_gpt":0.241851540963767,"score_spread":0.2356401106725086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}