{"id":"W3164338067","doi":"10.1038/s41523-021-00266-0","title":"Anti-tumor effects of an ID antagonist with no observed acquired resistance","year":2021,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Botwinick-Wolfensohn Foundation; Fonds de recherche du Québec – Nature et technologies; American Concrete Institute Foundation; Generalitat Valenciana; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation","keywords":"Paclitaxel; Cancer research; Biology; Reactive oxygen species; Transcription factor; Cell growth; Cancer; Cell biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004669369,0.0001756422,0.00022336,0.00001523836,0.00007065025,0.0000261972,0.0001951501,0.00007121034,0.00008941966],"category_scores_gemma":[0.00003966381,0.0001594262,0.00006111046,0.0001041723,0.000131132,0.000007974792,0.00006210872,0.00003987471,0.000004936895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002282399,"about_ca_system_score_gemma":0.0004349458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005581092,"about_ca_topic_score_gemma":0.0002935824,"domain_scores_codex":[0.9988992,0.00007291756,0.0001709947,0.00042877,0.0001848813,0.0002432826],"domain_scores_gemma":[0.9989475,0.00001456261,0.0001187147,0.0005228192,0.0002918573,0.000104543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005718936,0.0001892286,0.01444045,0.0003291038,0.0001039612,0.00008542748,0.00001542495,0.00004628802,0.982781,0.00000814212,0.000989504,0.0004395829],"study_design_scores_gemma":[0.0009209188,0.00008538421,0.1588528,0.0001907035,0.00005322099,0.00002916933,0.00001370879,0.000009403288,0.8332027,0.000003873127,0.006428659,0.0002094459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958188,0.003182081,0.00006322068,0.00007963994,0.0001865213,0.0001256579,0.000229414,0.000021715,0.0002929325],"genre_scores_gemma":[0.9975958,0.00004732161,0.0007342916,0.0003670459,0.0003439403,0.00005086311,0.0001875602,0.00003993542,0.0006332232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495783,"threshold_uncertainty_score":0.6501211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006295913903447121,"score_gpt":0.2335889986771677,"score_spread":0.2272930847737206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}