{"id":"W3164338067","doi":"10.1038/s41523-021-00266-0","title":"Anti-tumor effects of an ID antagonist with no observed acquired resistance","year":2021,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Botwinick-Wolfensohn Foundation; Fonds de recherche du Québec – Nature et technologies; American Concrete Institute Foundation; Generalitat Valenciana; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation","keywords":"Paclitaxel; Cancer research; Biology; Reactive oxygen species; Transcription factor; Cell growth; Cancer; Cell biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009661725,0.0002042074,0.0003689138,0.0001764353,0.0001253843,0.0002395286,0.0002366253,0.0002976257,0.002779534],"category_scores_gemma":[0.0001038613,0.00008377925,0.0001675759,0.0001138911,0.0001392955,0.0001365049,0.00007606112,0.0007037122,0.0004351472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607894,"about_ca_system_score_gemma":0.0002634746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003807358,"about_ca_topic_score_gemma":0.0008648056,"domain_scores_codex":[0.9999342,0.00001254576,0.000005191585,0.000009868476,0.00001232269,0.00002581706],"domain_scores_gemma":[0.9999473,0.00001236221,0.000007364065,0.00000862169,0.000006734909,0.0000175919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001627355,0.0010554,0.0005134973,0.000174281,0.00004520662,0.0003364184,0.00003427119,0.0003798009,0.9688292,0.0006555394,0.001172392,0.02517664],"study_design_scores_gemma":[0.001158444,0.02005836,0.01427957,0.0000319321,0.0001225938,0.00294724,0.00007890206,0.002437782,0.9285656,0.0002086089,0.03008247,0.00002839512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892437,0.003099293,0.000704759,0.000265304,0.0001116604,0.00007199735,0.0005766936,0.0001294232,0.005797212],"genre_scores_gemma":[0.992036,0.001317019,0.0007974764,0.0001543162,0.00002381665,0.00004284822,0.001001411,0.00001206623,0.004615088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779534,"threshold_uncertainty_score":0.009298503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006295913903447121,"score_gpt":0.2335889986771677,"score_spread":0.2272930847737206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}