{"id":"W3164370300","doi":"10.1038/s41388-021-01841-2","title":"Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches","year":2021,"lang":"en","type":"review","venue":"Oncogene","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Receptor tyrosine kinase; Biology; Receptor Protein-Tyrosine Kinases; Cancer research; Tyrosine kinase; Cancer; Signal transduction; Receptor; Kinase; Targeted therapy; Bioinformatics; Computational biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005301963,0.0006007458,0.002497348,0.000228526,0.0001291764,0.00008732096,0.000198154,0.0005081004,0.0008412964],"category_scores_gemma":[0.0000894098,0.000469812,0.0003235613,0.0005469754,0.0002173736,0.00003253217,0.0002790923,0.0006889906,0.0000400415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004876299,"about_ca_system_score_gemma":0.001857297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001349008,"about_ca_topic_score_gemma":0.00002838116,"domain_scores_codex":[0.9969711,0.0003039211,0.0005668533,0.00100208,0.0005869162,0.0005691544],"domain_scores_gemma":[0.9983394,0.0002271628,0.0002073073,0.0006735947,0.0001189201,0.0004336507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001948511,0.00008979309,0.000008466953,0.01615241,0.0005638865,0.00008083031,0.00004830277,6.130012e-8,0.0006217534,0.0002588402,0.0008159032,0.9813403],"study_design_scores_gemma":[0.0005702816,0.0003396418,0.000002424315,0.01480185,0.001877245,0.0004880296,0.00005340274,0.000008655376,0.0006109779,0.00004077228,0.9807764,0.0004303392],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008829896,0.9968509,0.00003022971,0.0004414966,0.0003057678,0.001428042,0.0002052994,0.00006276826,0.0005871617],"genre_scores_gemma":[0.00004195807,0.9932958,0.001539508,0.0002044224,0.0006669707,0.0007016036,0.0002347994,0.0001833316,0.003131585],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809099,"threshold_uncertainty_score":0.9997754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2586330932450677,"score_gpt":0.4278230135802591,"score_spread":0.1691899203351915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}