{"id":"W3164391414","doi":"10.1101/2021.05.22.445261","title":"Non-coding <i>NFKBIZ</i> 3′ UTR mutations promote cell growth and resistance to targeted therapeutics in diffuse large B-cell lymphoma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia; Spinal Cord Injury BC; Simon Fraser University","funders":"National Cancer Institute; NIHR Cambridge Biomedical Research Centre; Canadian Institutes of Health Research; Medical Research Council; Terry Fox Research Institute; Cancer Research UK; Kay Kendall Leukaemia Fund; Michael Smith Health Research BC; Genome British Columbia; National Institute for Health and Care Research; Canada's Michael Smith Genome Sciences Centre; Genome Canada; U.S. Department of Health and Human Services; National Institutes of Health; Instituto Carlos Slim de la Salud","keywords":"Diffuse large B-cell lymphoma; Untranslated region; Biology; Cancer research; Mutation; Coding region; Somatic hypermutation; Germinal center; Biomarker; Lymphoma; Genetics; Gene; Computational biology; B cell; Messenger RNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528772,0.0001373904,0.000119906,0.0001287254,0.00009028082,0.0002657621,0.00009299532,0.0001453777,0.001193529],"category_scores_gemma":[0.00008614668,0.00006362289,0.0001177302,0.00008091014,0.0001474184,0.00007721382,0.00009410775,0.0003342585,0.0002796692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215303,"about_ca_system_score_gemma":0.00009995462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005020605,"about_ca_topic_score_gemma":0.0005497356,"domain_scores_codex":[0.9999189,0.00001523083,0.000006813532,0.000013106,0.00002547339,0.00002046442],"domain_scores_gemma":[0.9999377,0.0000134864,0.00001777325,0.000008323769,0.000005624254,0.00001715848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001811452,0.00005001496,0.001808321,0.00001441581,0.000005366213,0.0000697722,0.000009698312,0.00008528961,0.9957095,0.00006681524,0.00008158729,0.001917978],"study_design_scores_gemma":[0.00006293069,0.0008502687,0.05487243,0.000008192299,0.00002874979,0.001467613,0.00007115222,0.002185905,0.9369872,0.000136902,0.003324061,0.000004794997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975212,0.0007477963,0.0005055868,0.00008176387,0.000007333612,0.000009488806,0.0001350798,0.00004058804,0.00095108],"genre_scores_gemma":[0.9988897,0.0001684441,0.00018919,0.00002799234,0.000003047837,0.00000583393,0.0001445792,0.000004482997,0.0005666509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193529,"threshold_uncertainty_score":0.003992736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053394938334675,"score_gpt":0.2231523495457967,"score_spread":0.21261840016245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}