{"id":"W3164402145","doi":"10.1016/j.urolonc.2021.04.011","title":"Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma","year":2021,"lang":"en","type":"article","venue":"Urologic Oncology Seminars and Original Investigations","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Decipher Biosciences (Canada); University of British Columbia","funders":"","keywords":"Gene silencing; Cancer research; Biology; Bladder cancer; Pathology; Urothelial Cell; Cell growth; Cystectomy; Urothelium; Cell culture; Cancer; Small interfering RNA; Medicine; Transfection; Internal medicine; Urinary bladder; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006800072,0.0001201664,0.0001659521,0.00007919403,0.00007772658,0.00001010725,0.00005827683,0.0002383181,0.0001763884],"category_scores_gemma":[0.0002553801,0.0001186572,0.00005205466,0.0001702867,0.0002625301,0.00000936335,0.00004164555,0.0001377219,0.000005126029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004965574,"about_ca_system_score_gemma":0.0009229141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005296794,"about_ca_topic_score_gemma":0.0001123288,"domain_scores_codex":[0.9986457,0.0004212218,0.0002453947,0.0003205001,0.0001946414,0.0001725035],"domain_scores_gemma":[0.9994032,0.00002456074,0.0001066619,0.000169992,0.0002160705,0.00007952152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002225241,0.000547843,0.124417,0.00002374285,0.00009107368,0.00007780838,0.0003234263,0.005871487,0.8581728,0.004789333,0.002279317,0.003183562],"study_design_scores_gemma":[0.005505502,0.005025643,0.01184643,0.00004262254,0.0006593011,0.0006923681,0.00105544,0.01797839,0.481786,0.03228571,0.4425107,0.0006119086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887412,0.003631226,0.0001254216,0.001131431,0.0002022215,0.0001827787,0.00001754539,0.000007750384,0.005960381],"genre_scores_gemma":[0.9955549,0.0002400062,0.0022988,0.001229583,0.0001236032,0.00005482367,0.0001858571,0.000008635425,0.0003037874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4402314,"threshold_uncertainty_score":0.4838698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237407340800796,"score_gpt":0.2991380258558943,"score_spread":0.2753972917758147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}