{"id":"W3164411947","doi":"10.1091/mbc.e20-11-0699","title":"Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane","year":2021,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ergosterol; Biology; Phospholipid; Membrane; Flippase; Budding yeast; Cell biology; Budding; Yeast; Biophysics; Cell membrane; Biochemistry; Saccharomyces cerevisiae; Phosphatidylserine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128569,0.0007127792,0.000389141,0.0002312228,0.0002613993,0.0003018639,0.0002615903,0.0004200681,0.000984263],"category_scores_gemma":[0.0002233003,0.0001761472,0.0003358731,0.0001744016,0.0004154057,0.000267004,0.000395847,0.0004386201,0.0007342646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004257703,"about_ca_system_score_gemma":0.0003619311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037222,"about_ca_topic_score_gemma":0.0008097366,"domain_scores_codex":[0.9998816,0.00001518976,0.00001955705,0.00002528737,0.0000285632,0.00002974221],"domain_scores_gemma":[0.9997676,0.00004466309,0.00007289663,0.00001844286,0.00001916796,0.00007716782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001694881,0.00001094801,0.000354645,0.00004786306,0.000003832415,0.000268484,0.00001556912,0.00008640801,0.9975464,0.0001238555,0.00003958176,0.001333013],"study_design_scores_gemma":[0.00002791198,0.00005377609,0.01001619,0.00001024595,0.0000168808,0.001166023,0.00005892747,0.001471663,0.9847851,0.0001431183,0.002237103,0.00001309375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994031,0.001307833,0.003068926,0.0001608564,0.0000340757,0.00001198966,0.0006029749,0.0001456717,0.000636617],"genre_scores_gemma":[0.9960266,0.0004227003,0.001834275,0.00003329589,0.000006107089,0.00001004327,0.0005719333,0.00003188007,0.001063141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037222,"threshold_uncertainty_score":0.00329262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043461551787106,"score_gpt":0.2571966235601737,"score_spread":0.2467620080423026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}