{"id":"W3164429960","doi":"10.1002/mas.21706","title":"Recent advances in top‐down proteome sample processing ahead of MS analysis","year":2021,"lang":"en","type":"review","venue":"Mass Spectrometry Reviews","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Department of Energy; Dalhousie University","funders":"","keywords":"Proteomics; Proteome; Workflow; Computational biology; Chemistry; Characterization (materials science); Function (biology); Human proteome project; Nanotechnology; Computer science; Biology; Biochemistry; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504865,0.001488189,0.001214932,0.002183036,0.0003079027,0.001327055,0.001322514,0.001063621,0.003431642],"category_scores_gemma":[0.001283793,0.0005795772,0.000800717,0.00240781,0.0005450272,0.001892889,0.001040202,0.00217334,0.003788596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007002525,"about_ca_system_score_gemma":0.001176822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659975,"about_ca_topic_score_gemma":0.0008417015,"domain_scores_codex":[0.9993352,0.00008944323,0.00005450115,0.0001362509,0.0003259231,0.00005866803],"domain_scores_gemma":[0.9992837,0.0003395913,0.0000873193,0.0000305852,0.0002187038,0.00004004836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001656792,0.0001297024,0.0003134889,0.03099551,0.0002029319,0.000347944,0.0000983793,0.001349912,0.03482472,0.009015136,0.03263431,0.8899222],"study_design_scores_gemma":[0.00001611892,0.000175013,0.0006946713,0.00154679,0.0001428295,0.001095934,0.00004578193,0.0005979225,0.01292589,0.00319888,0.979505,0.00005526201],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000676667,0.9927164,0.003469379,0.0003691245,0.0004719453,0.00001991157,0.000066789,0.00009640012,0.002113468],"genre_scores_gemma":[0.001866775,0.9931117,0.00302587,0.0003204275,0.0003618033,0.00002508232,0.0001418414,0.00001664681,0.00112988],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003431642,"threshold_uncertainty_score":0.01148003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0470802010112216,"score_gpt":0.3770227709471039,"score_spread":0.3299425699358823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}