{"id":"W3164440149","doi":"10.1038/s41598-021-90403-3","title":"Efficacy, safety and tolerability of drugs studied in phase 3 randomized controlled trials in solid tumors over the last decade","year":2021,"lang":"en","type":"review","venue":"Scientific Reports","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Tolerability; Discontinuation; Internal medicine; Clinical endpoint; Hazard ratio; Adverse effect; Randomized controlled trial; Oncology; Odds ratio; Confidence interval; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1449058,0.001419848,0.007814251,0.004639656,0.0006127204,0.005611651,0.001359376,0.002797343,0.003643741],"category_scores_gemma":[0.2087037,0.001102775,0.01578251,0.008583883,0.001817807,0.00326923,0.001405525,0.002946761,0.0005152455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003876019,"about_ca_system_score_gemma":0.00540718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870221,"about_ca_topic_score_gemma":0.003967275,"domain_scores_codex":[0.8068078,0.1190124,0.04761738,0.009472779,0.01575306,0.001336653],"domain_scores_gemma":[0.7102345,0.2034161,0.06127363,0.008483265,0.01550629,0.001086194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.02750951,0.0003352729,0.02079264,0.4160522,0.3019544,0.0002167405,0.0004610764,0.002155084,0.001825675,0.003012008,0.008978146,0.2167073],"study_design_scores_gemma":[0.03654303,0.00838991,0.07088313,0.2260818,0.5457706,0.001126414,0.0004112715,0.001797474,0.002795026,0.009427601,0.09646583,0.000307792],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01018587,0.9758182,0.003616444,0.003155498,0.0007354065,0.001487775,0.002088529,0.00006365436,0.00284874],"genre_scores_gemma":[0.3427071,0.6144226,0.01696188,0.01020864,0.002134599,0.009094043,0.003415297,0.0001458294,0.0009100806],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1449058,"threshold_uncertainty_score":0.7663443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3904667026163213,"score_gpt":0.5871024553318834,"score_spread":0.1966357527155622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}