{"id":"W3164467092","doi":"10.3390/ijms22115767","title":"Challenging Safety and Efficacy of Retinal Gene Therapies by Retinogenesis","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Research Council; Fondazione Telethon","keywords":"Biology; Retinal; Transgene; Retinitis pigmentosa; Cell biology; Regulation of gene expression; Retina; Gene silencing; Gene expression; Gene; Genetics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002294751,0.0002784602,0.0004237831,0.0002948424,0.0002448427,0.0007296865,0.000400457,0.0004879992,0.0009799402],"category_scores_gemma":[0.001646902,0.00008346189,0.0002803766,0.0001056794,0.0007679965,0.0004874882,0.0003910081,0.001218478,0.000247185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469429,"about_ca_system_score_gemma":0.0005924637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002486776,"about_ca_topic_score_gemma":0.0002324868,"domain_scores_codex":[0.9984804,0.0004665578,0.00009153346,0.0001977903,0.0006742264,0.0000895715],"domain_scores_gemma":[0.9986888,0.0005347134,0.0003310823,0.0002010024,0.0001673829,0.00007711653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000707271,0.0002080411,0.001597357,0.0003696168,0.00007056863,0.0001703888,0.0001071184,0.0007554772,0.9277207,0.004233583,0.0003369034,0.06372306],"study_design_scores_gemma":[0.00007476593,0.005802815,0.002793787,0.0001013725,0.0001567404,0.001213784,0.0001252218,0.002362377,0.972498,0.00225345,0.01260376,0.00001395107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8579469,0.03304812,0.09661102,0.003333822,0.000380097,0.0003010614,0.0002019332,0.0003933914,0.007783778],"genre_scores_gemma":[0.9840407,0.005410152,0.008586189,0.0003095681,0.0001055997,0.00008862976,0.00008022487,0.00004004033,0.00133888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294751,"threshold_uncertainty_score":0.01213592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008433023413277754,"score_gpt":0.2603567017382719,"score_spread":0.2519236783249941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}