{"id":"W3164467092","doi":"10.3390/ijms22115767","title":"Challenging Safety and Efficacy of Retinal Gene Therapies by Retinogenesis","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Research Council; Fondazione Telethon","keywords":"Biology; Retinal; Transgene; Retinitis pigmentosa; Cell biology; Regulation of gene expression; Retina; Gene silencing; Gene expression; Gene; Genetics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003557187,0.0000697519,0.0001003628,0.00005729262,0.00004313649,0.0000311696,0.0002598671,0.00003573463,0.00001721093],"category_scores_gemma":[0.0001424732,0.0000597457,0.00007355408,0.00007418403,0.0001605268,0.000008239102,0.00008090702,0.00003936201,2.902765e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005812244,"about_ca_system_score_gemma":0.0001139091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002445888,"about_ca_topic_score_gemma":8.28575e-7,"domain_scores_codex":[0.9990971,0.00005103971,0.0002572605,0.000137165,0.0003704327,0.00008701714],"domain_scores_gemma":[0.9993817,0.00001975022,0.0001922374,0.00005477101,0.000313394,0.00003816136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001179829,0.00004142471,0.005359361,0.000003285404,0.0001087248,0.00003052289,0.0001030185,0.00009327689,0.98674,0.0002482731,0.0001052652,0.007048842],"study_design_scores_gemma":[0.0006719989,0.0001964637,0.01064723,0.0000426157,0.00001327117,0.0002421196,0.0003907245,0.00002226764,0.9825183,0.000193474,0.004954281,0.0001072867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818057,0.0118315,0.004169562,0.001214335,0.0001617486,0.0000194886,0.000003635458,0.000001090379,0.0007929496],"genre_scores_gemma":[0.9922674,0.004540382,0.002931078,0.0001485679,0.00004577512,2.786769e-7,0.00000754437,0.000004237016,0.00005475675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01046169,"threshold_uncertainty_score":0.2436359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008433023413277754,"score_gpt":0.2603567017382719,"score_spread":0.2519236783249941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}