{"id":"W3164477931","doi":"10.1016/j.dnarep.2021.103140","title":"Chromatin dynamics and DNA replication roadblocks","year":2021,"lang":"en","type":"review","venue":"DNA repair","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Université de Montréal","keywords":"Biology; Chromatin; Control of chromosome duplication; DNA replication; Origin recognition complex; Eukaryotic DNA replication; Histone; Pre-replication complex; Cell biology; DNA re-replication; DNA repair; Genetics; Semiconservative replication; DNA; Nucleosome; Histone code","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003948648,0.0004406339,0.0009159355,0.00007184389,0.00008302095,0.00004403788,0.0002650111,0.0007035657,0.00003265106],"category_scores_gemma":[0.0002630829,0.0004224564,0.0005901582,0.0001718955,0.00006061399,0.000003198904,0.0003847689,0.0001991147,0.00002436482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008669486,"about_ca_system_score_gemma":0.0002509758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007647768,"about_ca_topic_score_gemma":0.00002023914,"domain_scores_codex":[0.9975672,0.0001999235,0.000554473,0.001210792,0.0001760783,0.000291579],"domain_scores_gemma":[0.9975117,0.00002441308,0.0003394648,0.001911293,0.0000870158,0.0001261069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003904064,0.00007711571,0.000005612067,0.004365324,0.0003978685,0.00003196246,0.00001405811,2.633058e-7,0.002115919,0.0009058288,0.006537634,0.9855445],"study_design_scores_gemma":[0.0001096502,0.0001062525,0.000002090886,0.001498341,0.0002979564,0.0002634524,0.00001589393,0.0001686741,0.001779358,0.00002375788,0.9952862,0.0004483353],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000857999,0.9963312,0.0002129368,0.00002602119,0.0001993948,0.0006125338,0.00008668564,0.0001501166,0.001523136],"genre_scores_gemma":[0.00004886048,0.9890787,0.002312548,0.00008325923,0.0002505461,0.0002025099,0.00315811,0.0001065025,0.004758965],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9887486,"threshold_uncertainty_score":0.9998227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661675667500012,"score_gpt":0.2930974354232196,"score_spread":0.2764806787482195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}