{"id":"W3164492643","doi":"10.2337/db21-0037","title":"Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fraternal Order of Eagles; National Institute of General Medical Sciences; Beckman Research Institute, City of Hope; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Internal medicine; Endocrinology; Insulin; Glucose homeostasis; Islet; Biology; Secretion; Insulin oscillation; Pancreatic islets; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434997,0.00020408,0.0005270237,0.00008634297,0.00009181312,0.00004318959,0.0000264871,0.0001591147,0.0002543914],"category_scores_gemma":[0.0003234199,0.0001864166,0.00009919614,0.0002243338,0.0001028839,0.0001141045,0.00002485925,0.0001079758,0.00001062467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001861419,"about_ca_system_score_gemma":0.00008742169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001251998,"about_ca_topic_score_gemma":9.518312e-7,"domain_scores_codex":[0.9987739,0.00005721939,0.0003487374,0.0003743627,0.0001633754,0.0002824494],"domain_scores_gemma":[0.9988803,0.0003651666,0.0001330837,0.0002059109,0.0002639576,0.0001516102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003564444,0.0001521398,0.0346492,0.0008483098,0.0001858527,0.000001597637,0.0001915521,0.000007273627,0.9612569,0.0001210966,0.001162255,0.001067434],"study_design_scores_gemma":[0.008143986,0.00111847,0.02293828,0.0002886029,0.000941426,0.00000353139,0.0002775192,0.01406055,0.9484743,0.001477064,0.002013041,0.0002632384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944131,0.003028787,0.0003478617,0.0003000131,0.0002654846,0.0005025867,0.00007645746,0.00005288421,0.001012841],"genre_scores_gemma":[0.9954363,0.0003037625,0.001449579,0.0008335023,0.0001836129,0.00005249595,0.0003061672,0.00003019197,0.00140438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01405327,"threshold_uncertainty_score":0.7601849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117083979345982,"score_gpt":0.2301717484565433,"score_spread":0.2184633505219451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}