{"id":"W3164492643","doi":"10.2337/db21-0037","title":"Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fraternal Order of Eagles; National Institute of General Medical Sciences; Beckman Research Institute, City of Hope; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Internal medicine; Endocrinology; Insulin; Glucose homeostasis; Islet; Biology; Secretion; Insulin oscillation; Pancreatic islets; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001823967,0.0003738544,0.0004400786,0.0002560252,0.0001441841,0.0006980544,0.000432318,0.0003075193,0.001815976],"category_scores_gemma":[0.0002089102,0.0002322588,0.0002238315,0.0001923397,0.0004881318,0.000393809,0.0003650434,0.000710515,0.0003989536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952171,"about_ca_system_score_gemma":0.0003676733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005951761,"about_ca_topic_score_gemma":0.0007486466,"domain_scores_codex":[0.9998086,0.00002591922,0.0000331564,0.00005271766,0.00004736473,0.00003235645],"domain_scores_gemma":[0.9995925,0.00004981172,0.0001256233,0.0000640705,0.00002629964,0.0001416652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003159676,0.00002924251,0.0004685504,0.00004324208,0.000007565125,0.00009248416,0.00002079139,0.00004361453,0.9979051,0.0002302806,0.00002917952,0.0008139495],"study_design_scores_gemma":[0.00007151431,0.0002931975,0.01252893,0.0000243772,0.00005259278,0.0008448828,0.00009845737,0.001110074,0.9801762,0.0001509418,0.004635635,0.0000131023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993894,0.0009070005,0.003274214,0.0001064963,0.00003387874,0.00002291637,0.0006707027,0.00009510084,0.0009956475],"genre_scores_gemma":[0.9947187,0.0006404455,0.001756639,0.0000464425,0.00000932152,0.00003761093,0.0008300447,0.00007247222,0.001888268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815976,"threshold_uncertainty_score":0.006075025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117083979345982,"score_gpt":0.2301717484565433,"score_spread":0.2184633505219451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}