{"id":"W3164548357","doi":"10.1136/annrheumdis-2021-eular.282","title":"AB0197 EFFICACY AND SAFETY OF HLX01 COMBINED WITH METHOTREXATE IN CHINESE PATIENTS WITH MODERATELY TO SEVERELY ACTIVE RHEUMATOID ARTHRITIS WHO HAD INADEQUATE RESPONSES TO METHOTREXATE: RESULTS OF A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 STUDY","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of California, Los Angeles; University of Toronto","keywords":"Medicine; Rheumatoid arthritis; Placebo; Methotrexate; Internal medicine; Clinical endpoint; Rituximab; Rheumatology; Tolerability; Adverse effect; Clinical trial; Surgery; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001371203,0.001017899,0.002779436,0.0005425748,0.0005963708,0.0006903964,0.0007673261,0.001861064,0.004301605],"category_scores_gemma":[0.001215769,0.0005247043,0.00151528,0.0005387638,0.001518558,0.0009128664,0.0003616775,0.002004403,0.0007729546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000548451,"about_ca_system_score_gemma":0.0008850772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154344,"about_ca_topic_score_gemma":0.00172544,"domain_scores_codex":[0.9993625,0.000349384,0.00005146504,0.00008314481,0.00005793836,0.0000955693],"domain_scores_gemma":[0.9991635,0.0002564573,0.000154834,0.0000582899,0.00005947218,0.0003074366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9372176,0.01416397,0.00297833,0.0006820675,0.001392004,0.0001876747,0.000174248,0.0002121985,0.01223271,0.00007412904,0.0004175495,0.03026755],"study_design_scores_gemma":[0.7060964,0.280305,0.01063036,0.00002795722,0.0008701389,0.00008931367,0.00008104641,0.0003248455,0.0009917119,0.00006714249,0.0004828579,0.00003330451],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974862,0.001233383,0.0001178984,0.0001597731,0.00007542528,0.0003379933,0.0001056696,0.00002494388,0.0004587364],"genre_scores_gemma":[0.9970998,0.0007839976,0.0002610883,0.0003834168,0.0001767945,0.0003169864,0.000225306,0.000006570629,0.000746094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004301605,"threshold_uncertainty_score":0.01439029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03450348972195552,"score_gpt":0.3363933706583125,"score_spread":0.3018898809363569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}