{"id":"W3164548357","doi":"10.1136/annrheumdis-2021-eular.282","title":"AB0197 EFFICACY AND SAFETY OF HLX01 COMBINED WITH METHOTREXATE IN CHINESE PATIENTS WITH MODERATELY TO SEVERELY ACTIVE RHEUMATOID ARTHRITIS WHO HAD INADEQUATE RESPONSES TO METHOTREXATE: RESULTS OF A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 STUDY","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of California, Los Angeles; University of Toronto","keywords":"Medicine; Rheumatoid arthritis; Placebo; Methotrexate; Internal medicine; Clinical endpoint; Rituximab; Rheumatology; Tolerability; Adverse effect; Clinical trial; Surgery; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001516693,0.00042219,0.002140191,0.0002825966,0.0001208234,0.00002541872,0.0003485921,0.0001222323,0.00004909981],"category_scores_gemma":[0.003487948,0.0002347564,0.0002117201,0.0009109389,0.0003220233,0.0001256868,0.0002410871,0.0002100695,0.00000170022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001560388,"about_ca_system_score_gemma":0.0002283192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002289966,"about_ca_topic_score_gemma":0.0002048469,"domain_scores_codex":[0.9946923,0.002765154,0.001371961,0.0005396585,0.0002357396,0.0003951522],"domain_scores_gemma":[0.9940985,0.003637326,0.0007756842,0.0006836583,0.0006629609,0.0001419104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9675545,0.005111155,0.001616623,0.0001132711,0.002275225,0.000009271496,0.002272645,0.0002420798,0.0003698838,0.0000405035,0.00008364599,0.02031125],"study_design_scores_gemma":[0.7683861,0.006753266,0.1866988,0.002726649,0.0004671931,0.000007685361,0.001034507,0.00008233355,0.03309954,0.0002442912,0.00002742654,0.0004721377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924134,0.001303238,0.0001414165,0.001071928,0.00005756055,0.004158555,0.0007416969,0.00001456307,0.00009761607],"genre_scores_gemma":[0.9980828,0.0005217408,0.0007871439,0.000153797,0.000001978225,0.0001703833,0.00003197094,0.00002716608,0.0002229992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1991683,"threshold_uncertainty_score":0.9573088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03450348972195552,"score_gpt":0.3363933706583125,"score_spread":0.3018898809363569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}