{"id":"W3164553785","doi":"10.1017/cjn.2021.125","title":"Guidance on Gene Replacement Therapy in Spinal Muscular Atrophy: A Canadian Perspective","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Ottawa; University of British Columbia; Hospital for Sick Children; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Children's Hospital of Eastern Ontario; McGill University; McGill University Health Centre; SickKids Foundation; University of Toronto; Montreal Children's Hospital","funders":"Muscular Dystrophy Canada","keywords":"Spinal muscular atrophy; Medicine; Content (measure theory); Perspective (graphical); Physical medicine and rehabilitation; Pathology; Computer science; Disease; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.003048373,0.000331893,0.0005699305,0.001493335,0.001510354,0.0003897235,0.001085529,0.000180612,0.000347476],"category_scores_gemma":[0.002551744,0.0002372139,0.0003435205,0.001992005,0.003331506,0.0002992513,0.00004567996,0.001534913,0.000006846063],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008725446,"about_ca_system_score_gemma":0.01669092,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04364776,"about_ca_topic_score_gemma":0.5990143,"domain_scores_codex":[0.9946195,0.001068173,0.0007461818,0.0007622762,0.001123587,0.001680237],"domain_scores_gemma":[0.995331,0.0001687805,0.0003024673,0.0002612589,0.0009337205,0.003002785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007577166,0.0001542198,0.9034443,0.0000109852,0.00005293568,0.08192652,0.0005374265,0.00209413,0.0005851474,0.001989304,0.0005800122,0.007867334],"study_design_scores_gemma":[0.002219524,0.1837619,0.7287608,0.000155216,0.00004268411,0.06060717,0.001278116,0.0005219053,0.00146203,0.01079156,0.009870372,0.0005287686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971885,0.006137363,0.000009183178,0.01645622,0.0004483459,0.0002671595,0.000007276099,0.000007713278,0.004781705],"genre_scores_gemma":[0.9868396,0.001878456,0.00116489,0.009836278,0.0002117818,0.000005521657,4.13005e-7,0.00001571407,0.00004733893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5553665,"threshold_uncertainty_score":0.9997895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616796210471615,"score_gpt":0.3256338676760345,"score_spread":0.2794659055713183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}