{"id":"W3164553785","doi":"10.1017/cjn.2021.125","title":"Guidance on Gene Replacement Therapy in Spinal Muscular Atrophy: A Canadian Perspective","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Ottawa; University of British Columbia; Hospital for Sick Children; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Children's Hospital of Eastern Ontario; McGill University; McGill University Health Centre; SickKids Foundation; University of Toronto; Montreal Children's Hospital","funders":"Muscular Dystrophy Canada","keywords":"Spinal muscular atrophy; Medicine; Content (measure theory); Perspective (graphical); Physical medicine and rehabilitation; Pathology; Computer science; Disease; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007955783,0.0009438489,0.001422866,0.003038751,0.00210514,0.003829434,0.002733294,0.01160932,0.0190282],"category_scores_gemma":[0.01327088,0.0003321182,0.001545502,0.002976511,0.003552215,0.002802656,0.002098414,0.01066528,0.006262186],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01190995,"about_ca_system_score_gemma":0.06488838,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.5002826,"about_ca_topic_score_gemma":0.6890587,"domain_scores_codex":[0.9959241,0.0008661972,0.0004989707,0.0002761013,0.001916272,0.0005182889],"domain_scores_gemma":[0.9834133,0.003119788,0.0004842828,0.0002414541,0.01046202,0.002279097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000608175,0.0000603406,0.0002094177,0.0006762143,0.00001944384,0.0002629318,0.0002013023,0.0002621514,0.0004315712,0.00897493,0.8986945,0.09014641],"study_design_scores_gemma":[0.00004294602,0.00003641925,0.0004386049,0.002017628,0.00002789074,0.0002510811,0.0001174814,0.0000453564,0.00007258938,0.002420619,0.9945069,0.00002241663],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004960434,0.2318939,0.002273099,0.6910194,0.01773199,0.0001350226,0.001134919,0.0002411938,0.05507451],"genre_scores_gemma":[0.008523955,0.642634,0.01369299,0.2631393,0.01123704,0.0002892836,0.001445499,0.0002356818,0.05880231],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.98809,"threshold_uncertainty_score":0.9947413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616796210471615,"score_gpt":0.3256338676760345,"score_spread":0.2794659055713183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}