{"id":"W3164569496","doi":"10.1002/chem.202101373","title":"Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the <i>trans</i>‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute of Cancer Research; Canadian Cancer Society Research Institute; Wellcome Trust","keywords":"Amanita phalloides; Stereochemistry; Chemistry; Allosteric regulation; Biochemistry; Biological activity; Enzyme; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915602,0.0003179271,0.0002032323,0.0001332261,0.0001100323,0.0002318944,0.0002295678,0.0002874216,0.0005998767],"category_scores_gemma":[0.0001793148,0.0001264132,0.0002063573,0.0001381417,0.0001706239,0.0001995673,0.0001392125,0.0003302144,0.0002022409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000312175,"about_ca_system_score_gemma":0.0002142112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004110636,"about_ca_topic_score_gemma":0.000705538,"domain_scores_codex":[0.9999034,0.00002252271,0.00001049573,0.00001632151,0.00002566789,0.00002157186],"domain_scores_gemma":[0.9998794,0.00001230691,0.00004463747,0.000007930614,0.00002237597,0.00003345431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001226472,0.00008480997,0.0001061775,0.00005220638,0.000007771636,0.00009231726,0.00002509993,0.0008784461,0.9949849,0.0001142844,0.00003080691,0.003500481],"study_design_scores_gemma":[0.00008079757,0.002655295,0.0007724494,0.000006456163,0.00002618382,0.0002422822,0.00002089038,0.0008200279,0.9924077,0.00003518831,0.002923867,0.000008858839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893575,0.002028435,0.005532277,0.0001007578,0.00002631277,0.0002861758,0.0001973896,0.00004145533,0.002429748],"genre_scores_gemma":[0.9875965,0.001730312,0.008637809,0.00006416809,0.00001040518,0.0000864417,0.0003527348,0.00001239127,0.001509283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005998767,"threshold_uncertainty_score":0.002265036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04090558772791235,"score_gpt":0.2936620025212224,"score_spread":0.25275641479331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}