{"id":"W3164569496","doi":"10.1002/chem.202101373","title":"Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the <i>trans</i>‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute of Cancer Research; Canadian Cancer Society Research Institute; Wellcome Trust","keywords":"Amanita phalloides; Stereochemistry; Chemistry; Allosteric regulation; Biochemistry; Biological activity; Enzyme; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273556,0.00009863946,0.0002228408,0.0000207383,0.00007840578,0.00001238337,0.00008922869,0.00003977123,0.00004213129],"category_scores_gemma":[0.001108916,0.00007462255,0.0000757353,0.0001049761,0.0002199201,0.00003888449,0.00003139048,0.0002271998,1.605679e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000164542,"about_ca_system_score_gemma":0.0001711012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001375653,"about_ca_topic_score_gemma":4.355094e-7,"domain_scores_codex":[0.9988407,0.0003299487,0.0003997574,0.0001646607,0.0001433878,0.0001215667],"domain_scores_gemma":[0.9988877,0.0003014897,0.0002211995,0.0001489891,0.0003850434,0.00005560364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002370604,0.00009808341,0.005511118,0.0001001477,0.00006281888,0.00001485095,0.0001725095,0.00004621149,0.993422,0.00000585312,0.00009291637,0.0002364253],"study_design_scores_gemma":[0.001655731,0.000037373,0.0253536,0.0004466074,0.0002341897,0.0003629376,0.0002546242,0.001723179,0.9697378,0.00007183006,0.00005420582,0.00006786766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961659,0.0009234647,0.00184325,0.0007137564,0.00001508452,0.0001922774,0.0000289991,0.000004434549,0.0001128873],"genre_scores_gemma":[0.9978523,0.000180996,0.001729889,0.00006608858,0.00008042387,0.000006901338,0.00003371996,0.00001262988,0.00003710084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02368415,"threshold_uncertainty_score":0.3043019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04090558772791235,"score_gpt":0.2936620025212224,"score_spread":0.25275641479331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}