{"id":"W3164570079","doi":"10.1016/j.schres.2021.05.010","title":"Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment","year":2021,"lang":"en","type":"review","venue":"Schizophrenia Research","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Aripiprazole; Epigenetics; Risperidone; Antipsychotic; Schizophrenia (object-oriented programming); Olanzapine; Medicine; Clozapine; Pharmacogenetics; Dopamine hypothesis of schizophrenia; Psychiatry; Personalized medicine; Atypical antipsychotic; Bioinformatics; Psychology; Genetics; Dopamine; Biology; Gene; Internal medicine; Genotype; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142099,0.0009471159,0.0017533,0.001598186,0.000233271,0.001131109,0.00112362,0.001576876,0.004242584],"category_scores_gemma":[0.001652732,0.0002441839,0.0006194108,0.001738811,0.0005373327,0.001252195,0.0008619369,0.00242365,0.001419961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001099133,"about_ca_system_score_gemma":0.001589101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002106201,"about_ca_topic_score_gemma":0.005681113,"domain_scores_codex":[0.9997347,0.00008867612,0.00003349355,0.00004139193,0.00007918437,0.00002263082],"domain_scores_gemma":[0.9992398,0.0004771702,0.00007396626,0.00001871886,0.0001450139,0.00004538549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001061189,0.00006433982,0.0001840025,0.015923,0.0002358459,0.0001318436,0.00003823043,0.000475974,0.0008140908,0.005576889,0.04342049,0.9330293],"study_design_scores_gemma":[0.00005620268,0.00008946021,0.001113811,0.009901294,0.0004203776,0.0006369312,0.0000711533,0.0001748106,0.0002783194,0.006844965,0.9803812,0.00003154432],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002568831,0.9988666,0.00008431617,0.0005044224,0.00016325,0.000001695802,0.00001050128,0.000003977688,0.000339594],"genre_scores_gemma":[0.0002543691,0.9988304,0.0001521601,0.0003312224,0.0002098302,0.000002937999,0.00001518481,8.69142e-7,0.0002030268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004242584,"threshold_uncertainty_score":0.01419282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2349245116660923,"score_gpt":0.4622390664452077,"score_spread":0.2273145547791154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}