{"id":"W3164603569","doi":"10.1093/jncics/pkab029","title":"Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; World Cancer Research Fund; Medical Research Council; Hellenic Health Foundation; Institut Gustave-Roussy; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Harvard T.H. Chan School of Public Health; Canadian Cancer Society Research Institute; McGill University; Brigham and Women's Hospital; Associazione Italiana per la Ricerca sul Cancro; Damon Runyon Cancer Research Foundation; Agency for Healthcare Research and Quality; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Cancer Research UK; World Health Organization; European Commission; Johns Hopkins University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Colorectal cancer; MEDLINE; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006393876,0.00030171,0.0003604593,0.0008710502,0.0002306681,0.0005030209,0.0003251285,0.0003336314,0.002723502],"category_scores_gemma":[0.002450156,0.0001766811,0.000547291,0.001239986,0.0003545058,0.0002462289,0.0004082585,0.0004108591,0.0001913176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798811,"about_ca_system_score_gemma":0.0004747102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004061983,"about_ca_topic_score_gemma":0.00442279,"domain_scores_codex":[0.9994764,0.0001872982,0.00005327068,0.0001390574,0.00007187391,0.00007217751],"domain_scores_gemma":[0.9966711,0.0009266463,0.00149671,0.0002579376,0.0002689357,0.0003786208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009429416,0.00001613934,0.9980872,0.00003215137,0.0001100039,0.0000826604,0.00001398213,0.00005804527,0.0004114831,0.00002575171,0.0000310078,0.001037206],"study_design_scores_gemma":[0.000002093519,0.00003278198,0.999424,0.000005952652,0.0000454849,0.0001616438,0.00001954312,0.000105343,0.00006526885,0.00004999042,0.00008649597,0.00000143797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948088,0.002994731,0.000520587,0.0001110464,0.0000129508,0.000008856854,0.0008853205,0.00001359158,0.0006442162],"genre_scores_gemma":[0.9990827,0.0003187234,0.000192652,0.00001181543,0.00001611935,0.000003450977,0.0002509596,0.000002510483,0.000121102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004061983,"threshold_uncertainty_score":0.009111047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175229599209578,"score_gpt":0.307275362496326,"score_spread":0.2897524025753682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}