{"id":"W3164603569","doi":"10.1093/jncics/pkab029","title":"Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; World Cancer Research Fund; Medical Research Council; Hellenic Health Foundation; Institut Gustave-Roussy; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Harvard T.H. Chan School of Public Health; Canadian Cancer Society Research Institute; McGill University; Brigham and Women's Hospital; Associazione Italiana per la Ricerca sul Cancro; Damon Runyon Cancer Research Foundation; Agency for Healthcare Research and Quality; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Cancer Research UK; World Health Organization; European Commission; Johns Hopkins University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Colorectal cancer; MEDLINE; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221462,0.0001865867,0.0004728283,0.00009638142,0.0001048604,0.00001717623,0.00008013343,0.0001243303,0.0004266807],"category_scores_gemma":[0.0001245267,0.0001799856,0.0002271042,0.0003984447,0.00007297016,0.00004836619,0.00004410596,0.0001972195,0.000005719349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002808326,"about_ca_system_score_gemma":0.0006645176,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004831383,"about_ca_topic_score_gemma":0.01850571,"domain_scores_codex":[0.9985726,0.00003796602,0.000331441,0.0004116573,0.0002735252,0.0003727727],"domain_scores_gemma":[0.9990845,0.0001062031,0.0002088661,0.0002566156,0.000199539,0.0001442705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005821149,0.0001055425,0.9335534,0.0001991747,0.0001733432,0.00003701682,0.0005212758,0.00005698431,0.004026103,0.000006056113,0.0008183112,0.05468167],"study_design_scores_gemma":[0.001542886,0.001150865,0.6160748,0.0001542081,0.0002608793,0.00005319947,0.00005368073,0.0009386324,0.3785428,0.0001453995,0.0009251793,0.0001574142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930801,0.003856167,0.0002958248,0.0003003898,0.001224749,0.0004208625,0.0003695494,0.00006416567,0.0003882374],"genre_scores_gemma":[0.9966243,0.001078606,0.0005196948,0.0001030316,0.0006536862,0.0003616491,0.00000993599,0.00004157606,0.0006075111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3745168,"threshold_uncertainty_score":0.999404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175229599209578,"score_gpt":0.307275362496326,"score_spread":0.2897524025753682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}