{"id":"W3164605190","doi":"10.1101/2020.01.23.20018523","title":"Integrated genomics identify novel immunotherapy targets for malignant mesothelioma","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre","funders":"Medical Research Council","keywords":"CDKN2A; Cancer research; Immunotherapy; Mesothelioma; Biology; Neuroblastoma RAS viral oncogene homolog; Gene; Medicine; KRAS; Cancer; Pathology; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949981,0.000226538,0.0002814399,0.0002961454,0.0001190727,0.0004725877,0.0001296518,0.0003389266,0.002049309],"category_scores_gemma":[0.0001936434,0.00009826484,0.0002610056,0.0002632499,0.0001098424,0.0001269992,0.0002109689,0.0002842227,0.0004935173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329361,"about_ca_system_score_gemma":0.0001888758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002594579,"about_ca_topic_score_gemma":0.0003743818,"domain_scores_codex":[0.9999069,0.00001131867,0.000004301076,0.0000305002,0.00002937512,0.00001760715],"domain_scores_gemma":[0.9999293,0.00001946617,0.00002428174,0.000007714788,0.000007944529,0.00001119895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003766691,0.00005602724,0.01968988,0.0001684832,0.0000649615,0.0002617764,0.00005252582,0.001188424,0.9520836,0.0005676046,0.001249525,0.02424056],"study_design_scores_gemma":[0.0001201144,0.0009013332,0.3615725,0.00006918512,0.0004142135,0.00225772,0.0002613543,0.01910371,0.5652454,0.00461682,0.04540804,0.00002962245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721716,0.00450624,0.01053807,0.0008586529,0.00006982469,0.00004755617,0.007541384,0.0006607337,0.003605992],"genre_scores_gemma":[0.983705,0.001002142,0.00730559,0.000271636,0.00004036146,0.00003013524,0.00544746,0.00006268021,0.002135063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049309,"threshold_uncertainty_score":0.006855607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03895115626280945,"score_gpt":0.3012037734940028,"score_spread":0.2622526172311934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}