{"id":"W3164625461","doi":"10.1097/shk.0000000000001804","title":"Mechanistic Studies of DNase I Activity: Impact of Heparin Variants and PAD4.","year":2021,"lang":"en","type":"article","venue":"PubMed","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone; Neutrophil extracellular traps; Deoxyribonuclease I; Nucleosome; DNA; Molecular biology; Hypersensitive site; Heparin; DNase I hypersensitive site; Chemistry; Biochemistry; Biology; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005019631,0.0004023686,0.0001797335,0.0001180747,0.00009555276,0.0002437064,0.0003706077,0.0003513269,0.001296256],"category_scores_gemma":[0.0002504906,0.0001166398,0.0003555837,0.00009752829,0.0003452356,0.0002856094,0.0001593661,0.000417552,0.0002410123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003965344,"about_ca_system_score_gemma":0.0001722375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000388684,"about_ca_topic_score_gemma":0.0003300712,"domain_scores_codex":[0.9998463,0.00005169587,0.00001242027,0.00002966652,0.00002884438,0.00003106442],"domain_scores_gemma":[0.999846,0.00005142354,0.00004417633,0.00001567832,0.00001752148,0.00002513211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001040069,0.00008497587,0.00139988,0.000207041,0.00003331237,0.0001159183,0.0000171111,0.0003140552,0.9939578,0.0002698607,0.00005430013,0.002505753],"study_design_scores_gemma":[0.00004644545,0.001122904,0.005814803,0.000009829357,0.00002690103,0.0005154615,0.00002544178,0.001583602,0.9891295,0.0001032901,0.001615815,0.000006013834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818087,0.008401198,0.007721282,0.0002148121,0.00005343532,0.00007125684,0.000324553,0.00004241449,0.001362187],"genre_scores_gemma":[0.9925683,0.001703426,0.00420057,0.00009762064,0.00001461031,0.00004056337,0.0004850124,0.000004978906,0.0008850443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296256,"threshold_uncertainty_score":0.004336417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04708852891138732,"score_gpt":0.3261134836995718,"score_spread":0.2790249547881845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}