{"id":"W3164641364","doi":"10.1101/2021.02.18.21251945","title":"A glomerular transcriptomic landscape of <i>APOL1</i> in Black patients with focal segmental glomerulosclerosis","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; University of North Carolina at Chapel Hill; National Institutes of Health; Rare Diseases Clinical Research Network; Temple University; Children's Mercy Hospital; Washington University in St. Louis; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Wake Forest University; University of California, Los Angeles; University of Michigan; York University; University of Miami; Halpin Foundation; University of Washington; National Cancer Institute; Emory University; Cleveland Clinic; University of Pennsylvania; Nephcure Foundation","keywords":"Focal segmental glomerulosclerosis; Transcriptome; Gene; Biology; Glomerulosclerosis; Gene expression; Genetics; Immune system; Cell biology; Kidney; Glomerulonephritis; Proteinuria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063727,0.0001466031,0.0002914151,0.000764575,0.0002962685,0.0003554671,0.00008687386,0.0002489922,0.001009709],"category_scores_gemma":[0.0002366531,0.00008811089,0.0001846238,0.0005965966,0.0001972469,0.0001045444,0.0001832135,0.0001904854,0.0001047835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757952,"about_ca_system_score_gemma":0.00009394027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001722314,"about_ca_topic_score_gemma":0.002019724,"domain_scores_codex":[0.9998658,0.00001968604,0.000006916919,0.00005065956,0.00002279565,0.0000342308],"domain_scores_gemma":[0.999841,0.00003537545,0.00006408819,0.000007220422,0.0000207134,0.00003158983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001345781,0.00005606227,0.7597461,0.00005756293,0.0001343828,0.0009157838,0.0006102577,0.0002105324,0.2288707,0.00009706741,0.0002632875,0.007692451],"study_design_scores_gemma":[0.000005335748,0.00007814466,0.9958919,0.000004298186,0.000034607,0.0006471517,0.0003184626,0.0002844194,0.002443735,0.00005292577,0.0002335874,0.000005320901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994616,0.00009893654,0.00007032827,0.0000186707,9.22094e-7,0.000001543472,0.0002558582,0.000003302567,0.00008878964],"genre_scores_gemma":[0.9992291,0.00006205335,0.0001717146,0.00003067511,0.000003759133,0.000005033817,0.0003648334,0.000003278824,0.000129621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722314,"threshold_uncertainty_score":0.003424644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012382483969605,"score_gpt":0.2286250379527348,"score_spread":0.2185012131130387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}