{"id":"W3164654560","doi":"10.1016/j.ydbio.2021.05.016","title":"Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail","year":2021,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Iris O'Brien Foundation","keywords":"Notochord; Zebrafish; Cell biology; Biology; Myotome; Matrix metalloproteinase; Somite; Extracellular matrix; MMP9; MMP2; Morphogenesis; Anatomy; Embryogenesis; Downregulation and upregulation; Genetics; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126573,0.0003060846,0.0002602619,0.0005915178,0.0002231762,0.0005122654,0.0001827607,0.0003042334,0.001460071],"category_scores_gemma":[0.0002031283,0.00039673,0.0003368384,0.0002185944,0.0004244604,0.0003822547,0.0003056702,0.0008109466,0.0004910823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006603603,"about_ca_system_score_gemma":0.0003237691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003011647,"about_ca_topic_score_gemma":0.006949255,"domain_scores_codex":[0.9998597,0.00001048967,0.000009787729,0.00003357264,0.00003990395,0.00004652182],"domain_scores_gemma":[0.9996353,0.00003886105,0.0001412804,0.00001920072,0.00005170858,0.0001135886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001417219,0.000004660757,0.0008497456,0.00001592928,0.000003354192,0.00007598044,0.00002072527,0.00002317929,0.9983328,0.00009924007,0.00002714716,0.0004056358],"study_design_scores_gemma":[0.00002598961,0.0002041619,0.1727616,0.0000169696,0.00002455101,0.0005218809,0.0001340892,0.0006300869,0.8241417,0.0001245562,0.001397909,0.0000164033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994047,0.001570516,0.002217971,0.00007813361,0.00001542051,0.00001172503,0.0004579043,0.00004969426,0.00155162],"genre_scores_gemma":[0.9924845,0.000506034,0.001239355,0.00005783564,0.00001199845,0.0000347981,0.0005415304,0.00003379039,0.005090138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003011647,"threshold_uncertainty_score":0.00598824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006586426076901522,"score_gpt":0.203478793656356,"score_spread":0.1968923675794545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}