{"id":"W3164669447","doi":"10.1159/000515738","title":"TLR7 Ligation Inhibits TLR8 Responsiveness in IL-27-Primed Human THP-1 Monocytes and Macrophages","year":2021,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"TLR7; Cytokine; Biology; Chemokine; Proinflammatory cytokine; Toll-like receptor; Cell biology; TLR9; Immunology; Gene expression; Innate immune system; Inflammation; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003200879,0.0003325076,0.000367337,0.0001743572,0.0002190081,0.0002880937,0.0001779006,0.0002252627,0.001925637],"category_scores_gemma":[0.000176163,0.0001992555,0.0003133233,0.0001243695,0.0002772987,0.0001136782,0.0002515235,0.0006468737,0.001238778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874681,"about_ca_system_score_gemma":0.000412403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648018,"about_ca_topic_score_gemma":0.0005789254,"domain_scores_codex":[0.9996382,0.00009901235,0.00003161168,0.00003283091,0.00006445064,0.00013393],"domain_scores_gemma":[0.9998301,0.00004931039,0.00002482961,0.00002474019,0.00003084306,0.00004013596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009166838,0.0001528372,0.0002321007,0.00007868629,0.000008522003,0.0001058665,0.00004541925,0.00006254015,0.9968637,0.00007404832,0.0001438358,0.001315649],"study_design_scores_gemma":[0.0001325551,0.001446672,0.003209273,0.00001777311,0.00002439535,0.000249271,0.000102292,0.001079584,0.9906888,0.00006597218,0.002977625,0.000005864194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933258,0.001560172,0.002130575,0.0002296695,0.0000883007,0.00007431872,0.0003794767,0.00004453566,0.002167044],"genre_scores_gemma":[0.9899763,0.001714389,0.003423112,0.0002359663,0.00006535921,0.0002132107,0.001105538,0.00002770459,0.003238317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925637,"threshold_uncertainty_score":0.006441951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442379507275857,"score_gpt":0.2689994231006083,"score_spread":0.2545756280278497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}