{"id":"W3164672108","doi":"10.1371/journal.pntd.0009425","title":"Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus","year":2021,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Jewish General Hospital","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; H2020 European Institute of Innovation and Technology; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fondation de l'Hôpital général juif; Consejo Nacional de Ciencia y Tecnología; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; microRNA; Downregulation and upregulation; Transcription factor; Gene expression profiling; Microarray analysis techniques; Zika virus; Regulation of gene expression; Gene expression; Neural stem cell; Microarray; Immunology; Gene; Cell biology; Genetics; Virus; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134899,0.0004843458,0.0002847462,0.0003526319,0.0001713866,0.0003118573,0.0002672977,0.0003049806,0.001374858],"category_scores_gemma":[0.0001488122,0.0003289039,0.0003615375,0.0001284671,0.0003311349,0.0002045223,0.0002062391,0.0009324084,0.0004342895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003929682,"about_ca_system_score_gemma":0.0002107639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184925,"about_ca_topic_score_gemma":0.001285432,"domain_scores_codex":[0.9997237,0.00001959443,0.00002995677,0.0000859051,0.00007715965,0.00006368546],"domain_scores_gemma":[0.9997984,0.00002538464,0.00007279994,0.00001601322,0.00001775278,0.0000697402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007223253,0.000007083925,0.0001178195,0.0000133391,0.000003219519,0.00003316654,0.00001095301,0.00001133052,0.9994249,0.00002954133,0.00000930953,0.0002671095],"study_design_scores_gemma":[0.00001340066,0.0001925756,0.01147463,0.000009575813,0.00002524304,0.0002792646,0.00005206213,0.0005274625,0.9862337,0.00005929594,0.001126572,0.000006149022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923251,0.001794545,0.003469771,0.00008999395,0.00004145322,0.00002227761,0.001143567,0.0001218253,0.0009914906],"genre_scores_gemma":[0.9875815,0.001542816,0.004013676,0.00009152843,0.00001114532,0.00008601819,0.001458621,0.00007721673,0.005137454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374858,"threshold_uncertainty_score":0.004599392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353665212261712,"score_gpt":0.2322304053227613,"score_spread":0.2186937532001442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}