{"id":"W3164685102","doi":"10.3390/cells10061335","title":"Challenges with Methods for Detecting and Studying the Transcription Factor Nuclear Factor Kappa B (NF-κB) in the Central Nervous System","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Fondation de l’Hôpital Saint-Boniface","keywords":"Transcription factor; Biology; NF-κB; Neuroscience; Signal transduction; NFKB1; IκB kinase; Cell biology; Inflammation; Gene; Computational biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006420604,0.0003686732,0.000698555,0.00003883996,0.0001654936,0.00009927359,0.000360679,0.0003040712,0.000002474109],"category_scores_gemma":[0.00004785724,0.0002023336,0.0002471202,0.0000879795,0.0000519485,0.000003594792,0.0000574681,0.0003030385,8.621652e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004462311,"about_ca_system_score_gemma":0.00009180699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001031585,"about_ca_topic_score_gemma":0.00003193997,"domain_scores_codex":[0.9977041,0.0008907255,0.0003486913,0.0005640069,0.0001223968,0.0003700864],"domain_scores_gemma":[0.9989789,0.0002404903,0.0002107682,0.0004723992,0.00004745877,0.00005000268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001390038,0.00002946966,0.000001002198,0.007812038,0.0001920306,0.000007848853,0.001841799,0.000003493715,0.04220149,0.00003970796,0.00001088523,0.9478464],"study_design_scores_gemma":[0.0004102161,0.0003732894,0.00001232947,0.004280976,0.0005368868,0.0001207878,0.004970801,0.00002775798,0.01515135,0.000002574859,0.9735715,0.0005414953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003265708,0.992644,0.00219472,0.00002440134,0.0002845803,0.001443091,0.00005681619,0.00001712589,0.00006956451],"genre_scores_gemma":[0.02701325,0.9700673,0.002131259,0.00003175354,0.0004108586,0.0001729218,0.00004152372,0.0001032694,0.00002785418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9735606,"threshold_uncertainty_score":0.8250924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1190623330619128,"score_gpt":0.3474889320748228,"score_spread":0.2284265990129101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}