{"id":"W3164705475","doi":"10.1016/s0140-6736(21)00588-2","title":"Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":543,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Probity Medical Research","funders":"AbbVie","keywords":"Eczema Area and Severity Index; Atopic dermatitis; Medicine; Placebo; Internal medicine; Randomized controlled trial; Clinical trial; Clinical endpoint; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001097127,0.000308073,0.001878884,0.00006970335,0.0001515534,0.0000895344,0.0001579068,0.000150216,0.00003410721],"category_scores_gemma":[0.002059548,0.0001953256,0.0001068414,0.0001944314,0.0001367854,0.0001112215,0.00005768954,0.0003710577,0.00001263994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003122744,"about_ca_system_score_gemma":0.0002300462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161753,"about_ca_topic_score_gemma":0.0005428008,"domain_scores_codex":[0.997067,0.0008682781,0.0007295089,0.0005880889,0.0003570837,0.0003899954],"domain_scores_gemma":[0.9975465,0.0009818738,0.0002691984,0.0007410404,0.0002041241,0.0002572988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9839604,0.0001520319,0.00500629,0.0001125821,0.0004195309,0.0003688106,0.001445245,0.0000243689,0.0001318399,0.00001653772,0.00609731,0.002265],"study_design_scores_gemma":[0.987338,0.0001257669,0.007031861,0.001583715,0.000597552,0.0001420506,0.0004497328,0.0005660789,0.001345501,0.00009597302,0.0004772742,0.0002464878],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840873,0.003542779,0.0000598375,0.007394753,0.000265588,0.003167047,0.0003193505,0.00006916954,0.001094182],"genre_scores_gemma":[0.9967431,0.000365543,0.0000945793,0.001736251,0.0003464464,0.0002705039,0.0001904346,0.00002574289,0.000227399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01265581,"threshold_uncertainty_score":0.7965146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07452446434539767,"score_gpt":0.3370647134656402,"score_spread":0.2625402491202425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}