{"id":"W3164732396","doi":"10.1007/s43032-021-00630-2","title":"Environmental Pollutant Benzo[a]pyrene Upregulated Long Non-coding RNA HZ07 Inhibits Trophoblast Cell Migration by Inactivating PI3K/AKT/MMP2 Signaling Pathway in Recurrent Pregnancy Loss","year":2021,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trent University","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Trophoblast; Benzo(a)pyrene; PI3K/AKT/mTOR pathway; Protein kinase B; Gene knockdown; Downregulation and upregulation; Chemistry; Cell biology; MMP2; Cell migration; Biology; Signal transduction; Cancer research; Cell; Placenta; Biochemistry; Carcinogen; Apoptosis; Fetus; Pregnancy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281178,0.0001837059,0.0002173783,0.0002000197,0.000191489,0.0002264331,0.0001609881,0.0002263679,0.001893229],"category_scores_gemma":[0.0001550354,0.000162217,0.0003246432,0.000150442,0.0002017245,0.0001081718,0.000159453,0.0005689996,0.0002536342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473946,"about_ca_system_score_gemma":0.0003791676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001797404,"about_ca_topic_score_gemma":0.003441017,"domain_scores_codex":[0.9998043,0.00002950394,0.00001419163,0.00003729545,0.00005502141,0.00005966733],"domain_scores_gemma":[0.9999359,0.00001634383,0.00001623693,0.000007414012,0.000009297338,0.00001482541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005773774,0.0001173672,0.001106295,0.00005976925,0.00002190625,0.00008419817,0.00002583413,0.00008524284,0.9948067,0.00009554323,0.0001633247,0.002856332],"study_design_scores_gemma":[0.00008432232,0.001431752,0.03267219,0.00001042407,0.0001038972,0.0002361824,0.0001281131,0.001216159,0.9605872,0.00007106768,0.003447415,0.00001138895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995926,0.00145319,0.001064782,0.0001514598,0.0000733777,0.00001824739,0.0003978082,0.00006275238,0.0008524359],"genre_scores_gemma":[0.9947804,0.001056392,0.0006064623,0.00008828448,0.00001081695,0.000040813,0.000592859,0.000010551,0.002813512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001893229,"threshold_uncertainty_score":0.00633347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019067087674061,"score_gpt":0.2452687172380941,"score_spread":0.2350780463613535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}