{"id":"W3164732396","doi":"10.1007/s43032-021-00630-2","title":"Environmental Pollutant Benzo[a]pyrene Upregulated Long Non-coding RNA HZ07 Inhibits Trophoblast Cell Migration by Inactivating PI3K/AKT/MMP2 Signaling Pathway in Recurrent Pregnancy Loss","year":2021,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trent University","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Trophoblast; Benzo(a)pyrene; PI3K/AKT/mTOR pathway; Protein kinase B; Gene knockdown; Downregulation and upregulation; Chemistry; Cell biology; MMP2; Cell migration; Biology; Signal transduction; Cancer research; Cell; Placenta; Biochemistry; Carcinogen; Apoptosis; Fetus; Pregnancy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006762198,0.0002822975,0.000246273,0.0001471118,0.0003268971,0.0001053353,0.0002902338,0.0001709544,0.00004357414],"category_scores_gemma":[0.0002583463,0.0002885262,0.0001031155,0.0007986595,0.0002856161,0.00004726161,0.0003130674,0.0003095921,0.000006296261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298456,"about_ca_system_score_gemma":0.0003437573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006691661,"about_ca_topic_score_gemma":0.00006320189,"domain_scores_codex":[0.9964824,0.0002350926,0.0004559929,0.00161203,0.0006120271,0.0006024179],"domain_scores_gemma":[0.9990522,0.00002140943,0.0002410813,0.0004756917,0.00009510164,0.0001145133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005582085,0.0002042297,0.0002317541,0.00002848794,0.00002035429,0.00004280435,0.0003749845,0.001669305,0.9854702,0.000005805295,0.0000243401,0.01187194],"study_design_scores_gemma":[0.0005210984,0.0005110374,0.0003161419,0.0002882496,0.000007663919,0.00004065345,0.0007425595,0.0006062279,0.9964638,0.0000539639,0.0001121191,0.0003364673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866734,0.005656033,0.006385191,0.0002224034,0.0002488497,0.0004527692,0.00004783494,0.00001405287,0.0002994747],"genre_scores_gemma":[0.9981933,0.0004506511,0.0007153953,0.00002447586,0.0001671162,0.0000442841,0.0000997987,0.00003124942,0.0002737075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01153547,"threshold_uncertainty_score":0.9999567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019067087674061,"score_gpt":0.2452687172380941,"score_spread":0.2350780463613535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}