{"id":"W3164747304","doi":"10.1002/ana.26131","title":"Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Centre for Addiction and Mental Health","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; National Institutes of Health","keywords":"Polygenic risk score; Limiting; Disease; Ethnic group; Demography; Medicine; Alzheimer's disease; Caribbean region; Gerontology; Biology; Internal medicine; Genetics; Gene; Single-nucleotide polymorphism; Genotype; Latin Americans","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561821,0.0006465052,0.0002514863,0.00156348,0.0004141422,0.0005830539,0.000298229,0.000302801,0.002215802],"category_scores_gemma":[0.00540467,0.0001361598,0.0007312563,0.0008570796,0.0002124872,0.0002664484,0.000779917,0.0004091339,0.0002479919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003221293,"about_ca_system_score_gemma":0.0003950342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01715794,"about_ca_topic_score_gemma":0.01477959,"domain_scores_codex":[0.9995784,0.0001810722,0.00004366267,0.00008839816,0.00007086158,0.00003762766],"domain_scores_gemma":[0.9983741,0.0003846638,0.0006614628,0.0001653172,0.0002576355,0.0001567194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002129066,0.00002564309,0.9938483,0.00001325873,0.0001951603,0.00006972617,0.00007807546,0.0004004707,0.0002519168,0.00007249047,0.00018641,0.004645647],"study_design_scores_gemma":[0.00002309388,0.0001339565,0.9942201,0.00002243891,0.0001490576,0.000270719,0.0001695631,0.004288465,0.0001861688,0.0001896475,0.0003368079,0.00000988458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976941,0.0001453921,0.0005989675,0.00007180474,0.000005510968,0.00002038367,0.0007455366,0.00002457849,0.0006937756],"genre_scores_gemma":[0.9982906,0.00006246164,0.0006357913,0.00001067773,0.000006883692,0.00001790097,0.0007789559,0.000004174473,0.0001925898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01715794,"threshold_uncertainty_score":0.03411615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05301007536835615,"score_gpt":0.3181488248538808,"score_spread":0.2651387494855246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}