{"id":"W3164768471","doi":"10.1002/cpt.2311","title":"Interaction Between SNP Genotype and Efficacy of Anastrozole and Exemestane in Early‐Stage Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Cancer Society","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Cancer Society","keywords":"Exemestane; Anastrozole; Oncology; Breast cancer; Single-nucleotide polymorphism; Medicine; Aromatase inhibitor; Internal medicine; Aromatase; SNP; Tamoxifen; Genotype; Cancer; Bioinformatics; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007128049,0.000152047,0.0004298974,0.0002281005,0.0001453663,0.0003050393,0.0001654668,0.0004495185,0.001302278],"category_scores_gemma":[0.002156576,0.0001132318,0.0006941331,0.0002418555,0.0001608461,0.0001253394,0.0001333029,0.0004605864,0.0001612921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001419581,"about_ca_system_score_gemma":0.0001707811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007931473,"about_ca_topic_score_gemma":0.001331454,"domain_scores_codex":[0.9992206,0.0004131058,0.00007314971,0.0001264911,0.00008434107,0.00008236554],"domain_scores_gemma":[0.9978476,0.001489238,0.0003256339,0.0001005873,0.00005245924,0.0001845106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02470748,0.0003227146,0.9270167,0.00005757426,0.00249101,0.0006530558,0.0001555838,0.001050177,0.03068211,0.0001575878,0.0003248355,0.01238106],"study_design_scores_gemma":[0.0002303288,0.002397364,0.9911348,0.00000809613,0.0008468116,0.0005474617,0.00006303383,0.002062397,0.002108697,0.0001486286,0.0004396994,0.00001283323],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993796,0.0002387837,0.0001006337,0.00004634693,0.00001167255,0.000001973269,0.0001006956,0.000003525604,0.0001167576],"genre_scores_gemma":[0.9996865,0.00002522469,0.00006670393,0.00001826054,0.000006379405,0.000002724396,0.00006750014,0.000002078716,0.0001246498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302278,"threshold_uncertainty_score":0.004356563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04359414938016718,"score_gpt":0.4054828458177262,"score_spread":0.361888696437559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}