{"id":"W3164769147","doi":"10.15252/embj.2020107294","title":"Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters","year":2021,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"European Synchrotron Radiation Facility; European Commission; Medical Research Council; Kidney Foundation of Canada; Wellcome Trust","keywords":"Cotransporter; Phosphorylation; Biology; Intracellular; Nucleotide; Cytoplasm; Mutant; Cell biology; Cytosol; Chloride channel; Ion transporter; Biochemistry; Binding site; Biophysics; Sodium; Chemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002965576,0.00009988863,0.0001112442,0.0000398048,0.0001573214,0.00007842981,0.0001185438,0.00006270171,0.0000782351],"category_scores_gemma":[0.00001200868,0.00007750035,0.00006162135,0.0001033943,0.00004929103,0.00001702839,0.00001310139,0.0001405783,0.000001701302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001544578,"about_ca_system_score_gemma":0.00006402727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007554062,"about_ca_topic_score_gemma":0.00005690606,"domain_scores_codex":[0.9992599,0.0000484187,0.0002367474,0.0001483181,0.0001318642,0.0001746921],"domain_scores_gemma":[0.999632,0.000009779227,0.00009650437,0.0001190066,0.00008032035,0.00006240623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004879129,0.00005944297,0.09802512,0.00002041503,0.0000963249,0.00009124629,0.0004091331,0.003180238,0.8944963,0.0002128914,0.0007079301,0.002213077],"study_design_scores_gemma":[0.0029138,0.00007113609,0.4914285,0.00007798199,0.00006395751,0.0004500796,0.0004107628,0.0007506433,0.4963873,0.001120905,0.006054003,0.0002709285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994231,0.0004522544,0.003383919,0.001309284,0.000325662,0.00007221691,0.000006213709,0.000004423189,0.0002150516],"genre_scores_gemma":[0.9986875,0.0003423602,0.00003045665,0.0002840206,0.0003265381,0.0000026955,0.0000523591,0.00001326167,0.0002607806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.398109,"threshold_uncertainty_score":0.3160373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009255618022383437,"score_gpt":0.236482247053192,"score_spread":0.2272266290308085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}