{"id":"W3164769147","doi":"10.15252/embj.2020107294","title":"Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters","year":2021,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"European Synchrotron Radiation Facility; European Commission; Medical Research Council; Kidney Foundation of Canada; Wellcome Trust","keywords":"Cotransporter; Phosphorylation; Biology; Intracellular; Nucleotide; Cytoplasm; Mutant; Cell biology; Cytosol; Chloride channel; Ion transporter; Biochemistry; Binding site; Biophysics; Sodium; Chemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007796919,0.0001617385,0.0001463528,0.00007717326,0.0001948689,0.0002822912,0.0002101482,0.0003250547,0.0005125148],"category_scores_gemma":[0.00008994294,0.0001146075,0.0001096738,0.00007289972,0.0004406268,0.0004155522,0.0001795819,0.0002188499,0.000162177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655944,"about_ca_system_score_gemma":0.0001429086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000551805,"about_ca_topic_score_gemma":0.0005613762,"domain_scores_codex":[0.9999636,0.000005088675,0.000002766378,0.00001135988,0.000008615667,0.000008563731],"domain_scores_gemma":[0.9999421,0.000007683564,0.0000249867,0.000004912915,0.000005375678,0.00001489715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008588105,0.000004817644,0.0002505817,0.00002055251,0.000001613924,0.00006525877,0.00002272286,0.0003158919,0.9977821,0.0006929811,0.00002616208,0.0007314319],"study_design_scores_gemma":[0.0000484175,0.0001124177,0.0243342,0.00001418903,0.00001281647,0.0007366206,0.00009037681,0.01338804,0.9562935,0.002023516,0.002919368,0.00002659018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936746,0.001435222,0.003957539,0.0001038431,0.00001533898,0.000003883753,0.00004827801,0.00003421464,0.0007271813],"genre_scores_gemma":[0.9983077,0.0004484651,0.000844435,0.0000249871,0.00000480947,0.000004123078,0.00003108189,0.000006473152,0.000328004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000551805,"threshold_uncertainty_score":0.001927078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009255618022383437,"score_gpt":0.236482247053192,"score_spread":0.2272266290308085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}