{"id":"W3164773505","doi":"10.1093/neuonc/noab136","title":"Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Deutsche Kinderkrebsstiftung; Brain Tumour Charity","keywords":"DNA methylation; Atypical teratoid rhabdoid tumor; Methylation; Medicine; Glioma; Neuroblastoma; Retrospective cohort study; Oncology; Pathology; Internal medicine; Biology; Immunohistochemistry; Cancer research; DNA; Gene; Genetics; Cell culture; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003411975,0.0003937996,0.0003222586,0.001185176,0.0002950406,0.0006112235,0.0002331625,0.0002084186,0.0008703599],"category_scores_gemma":[0.005026742,0.0001783187,0.000463227,0.0013952,0.0005421048,0.0005031446,0.0004820157,0.0002696629,0.0002840374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002990515,"about_ca_system_score_gemma":0.0003350638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227689,"about_ca_topic_score_gemma":0.001215132,"domain_scores_codex":[0.9984161,0.0006183803,0.0002411593,0.0004514275,0.0001795084,0.00009347255],"domain_scores_gemma":[0.9962225,0.001139374,0.001168376,0.0007398175,0.000524228,0.0002057654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000381288,0.00003247137,0.989704,0.00003339287,0.0001424168,0.0001779935,0.0001759374,0.0001181366,0.001026767,0.00004509088,0.0001099408,0.008052606],"study_design_scores_gemma":[0.00002541584,0.000459569,0.9929766,0.00003838794,0.0005705032,0.001963537,0.0004133125,0.0003031946,0.0009741723,0.00004564384,0.002215311,0.00001423032],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941942,0.00216294,0.001488675,0.00004565459,0.00001080624,0.00003367434,0.0006603609,0.00001120186,0.00139243],"genre_scores_gemma":[0.9977798,0.0007140618,0.0004772418,0.00003268224,0.00001669225,0.00002507244,0.0008545798,0.000009988416,0.00008989908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003411975,"threshold_uncertainty_score":0.01804447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947916006918415,"score_gpt":0.3651712102795587,"score_spread":0.3356920502103745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}