{"id":"W3164773505","doi":"10.1093/neuonc/noab136","title":"Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Deutsche Kinderkrebsstiftung; Brain Tumour Charity","keywords":"DNA methylation; Atypical teratoid rhabdoid tumor; Methylation; Medicine; Glioma; Neuroblastoma; Retrospective cohort study; Oncology; Pathology; Internal medicine; Biology; Immunohistochemistry; Cancer research; DNA; Gene; Genetics; Cell culture; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116019,0.0001213009,0.0003671295,0.000125117,0.00004463455,0.000008481651,0.000161494,0.000051578,0.00004363358],"category_scores_gemma":[0.001499611,0.0001124704,0.0001148153,0.000192854,0.0001109823,0.00006152254,0.00008836469,0.0001646399,0.000002334618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001433124,"about_ca_system_score_gemma":0.0005612121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002400565,"about_ca_topic_score_gemma":0.00007322331,"domain_scores_codex":[0.9986266,0.0001619638,0.0003938763,0.0003765051,0.0002331108,0.0002079606],"domain_scores_gemma":[0.9978147,0.0005908947,0.0001988576,0.0004401981,0.0008361568,0.0001191541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002135976,0.006584098,0.0184966,0.00004635972,0.0004837005,0.000628991,0.0004737565,0.000005136906,0.9672169,0.0008245807,0.0002881917,0.002815705],"study_design_scores_gemma":[0.0233754,0.03445436,0.3669586,0.00004062845,0.000522748,0.0003893969,0.001494259,0.0003568949,0.5645595,0.001911838,0.005751982,0.0001844233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994713,0.0000597165,0.0001865172,0.001414794,0.0002236805,0.001256537,0.0006366896,0.00002211989,0.001486921],"genre_scores_gemma":[0.9983107,0.00007325186,0.0006341232,0.000437428,0.0000597257,0.0002295548,0.0001542298,0.00002508945,0.00007584993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4026574,"threshold_uncertainty_score":0.4586412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947916006918415,"score_gpt":0.3651712102795587,"score_spread":0.3356920502103745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}