{"id":"W3164788547","doi":"10.1136/annrheumdis-2021-eular.1434","title":"POS0406 miRNAs DEREGULATED IN RESPONSE TO IL17A INHIBITORS IN PSORIATIC ARTHRITIS REGULATE GENE PRODUCTS IN Rho-GTPase PATHWAYS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation; University of Toronto; Memorial University of Newfoundland","funders":"UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Celgene; Gilead Sciences; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"MiRBase; Fold change; microRNA; Psoriatic arthritis; Transcriptome; Medicine; Gene; RNA extraction; RNA; Gene expression; Molecular biology; Cancer research; Biology; Immunology; Psoriasis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000573155,0.0002197781,0.0005888765,0.0004729436,0.00004381729,0.0000293548,0.0001627129,0.00007106393,0.000095198],"category_scores_gemma":[0.005023058,0.0001818525,0.0001797198,0.001484954,0.00006409832,0.0001415019,0.0001268873,0.0001984045,0.00001939857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007634716,"about_ca_system_score_gemma":0.0005378096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000465249,"about_ca_topic_score_gemma":0.0004875875,"domain_scores_codex":[0.9975374,0.0003810415,0.0009413706,0.0003835942,0.0003831433,0.000373481],"domain_scores_gemma":[0.998401,0.0002694475,0.0001995804,0.0007255477,0.0002457393,0.0001586462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01275529,0.01228052,0.04807173,0.002778257,0.0004627159,0.00236515,0.01244925,0.0113683,0.738233,0.0008935895,0.01516403,0.1431781],"study_design_scores_gemma":[0.003265287,0.000297286,0.6554081,0.01328542,0.00005530488,0.00009382506,0.0008203094,0.0009242325,0.3229562,0.002165494,0.0003907188,0.0003378774],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844805,0.00226567,0.000002179335,0.01213051,0.0002793589,0.0006885,0.00007359008,0.0000264718,0.00005322562],"genre_scores_gemma":[0.9985362,0.000299848,0.0001805353,0.0006603803,0.00004938628,0.00006976271,0.00003313568,0.00003211473,0.000138677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6073363,"threshold_uncertainty_score":0.741573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03934218975155715,"score_gpt":0.2916011302985071,"score_spread":0.25225894054695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}