{"id":"W3164788547","doi":"10.1136/annrheumdis-2021-eular.1434","title":"POS0406 miRNAs DEREGULATED IN RESPONSE TO IL17A INHIBITORS IN PSORIATIC ARTHRITIS REGULATE GENE PRODUCTS IN Rho-GTPase PATHWAYS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation; University of Toronto; Memorial University of Newfoundland","funders":"UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Celgene; Gilead Sciences; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"MiRBase; Fold change; microRNA; Psoriatic arthritis; Transcriptome; Medicine; Gene; RNA extraction; RNA; Gene expression; Molecular biology; Cancer research; Biology; Immunology; Psoriasis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294682,0.0003539889,0.0005196443,0.0004166557,0.0004383816,0.0006532976,0.0001809839,0.0005378267,0.00510894],"category_scores_gemma":[0.0004631167,0.0002585728,0.0005319156,0.0003632549,0.0003257878,0.0002545709,0.0002906335,0.001072876,0.001448224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262209,"about_ca_system_score_gemma":0.0004229909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006373962,"about_ca_topic_score_gemma":0.001159336,"domain_scores_codex":[0.9995242,0.00005918794,0.0000460338,0.0001005172,0.0001670595,0.0001030163],"domain_scores_gemma":[0.9998237,0.00003559277,0.00006129602,0.00001315919,0.00003391776,0.00003225757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004352571,0.0001698787,0.01413428,0.0006791142,0.0003117174,0.000855989,0.0001982578,0.0005533853,0.943478,0.001085379,0.003338904,0.03084257],"study_design_scores_gemma":[0.0006155454,0.001993332,0.2371482,0.000184294,0.001153589,0.00427689,0.0007231762,0.005066819,0.6761518,0.002200997,0.07037747,0.0001078812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579458,0.01402409,0.006959612,0.0008008788,0.00119578,0.00009119308,0.006320781,0.0005101667,0.01215169],"genre_scores_gemma":[0.9830381,0.002274124,0.003327371,0.0008652561,0.000103303,0.0001272385,0.002668518,0.0001296719,0.007466337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00510894,"threshold_uncertainty_score":0.01709116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03934218975155715,"score_gpt":0.2916011302985071,"score_spread":0.25225894054695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}