{"id":"W3164794063","doi":"10.1042/bcj20210171","title":"CLN5 and CLN3 function as a complex to regulate endolysosome function","year":2021,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Retromer; Endocytic cycle; Cell biology; Endosome; Biology; Batten disease; Neuronal ceroid lipofuscinosis; Autophagy; Function (biology); GTPase-activating protein; Endocytosis; Biochemistry; Receptor; Signal transduction; Intracellular; Gene; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000203868,0.000139877,0.0002434051,0.0001200614,0.0001479581,0.00009574851,0.00006497285,0.0001337219,0.001348599],"category_scores_gemma":[0.0004289239,0.000121772,0.0001117237,0.0003583924,0.00006626778,0.00007933842,0.0001081525,0.0004679193,0.0001688625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343413,"about_ca_system_score_gemma":0.0001741769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000108507,"about_ca_topic_score_gemma":0.000001645175,"domain_scores_codex":[0.9984638,0.00006586463,0.0002683176,0.0002973198,0.0005500903,0.0003546224],"domain_scores_gemma":[0.998745,0.00004124831,0.00005250839,0.0001921571,0.0003374396,0.0006316126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001323634,0.0001475196,0.002842643,0.00003930547,0.0001089749,0.0002637051,0.00005190478,7.643505e-7,0.9513616,0.0001720295,0.02687669,0.01681126],"study_design_scores_gemma":[0.0122908,0.003891801,0.3387163,0.0005647351,0.0005952581,0.02666448,0.001283725,0.0002890384,0.3430762,0.007827164,0.26389,0.0009105042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888475,0.001680547,0.001014223,0.005809712,0.0002122497,0.0001623222,0.000003316963,0.00003758701,0.002232561],"genre_scores_gemma":[0.9942788,0.0001468974,0.0008186077,0.002209544,0.000708067,0.000006615133,0.00003561892,0.00002423832,0.001771566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6082854,"threshold_uncertainty_score":0.9995643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03196891402720697,"score_gpt":0.3100882142362491,"score_spread":0.2781193002090421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}