{"id":"W3164794063","doi":"10.1042/bcj20210171","title":"CLN5 and CLN3 function as a complex to regulate endolysosome function","year":2021,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Retromer; Endocytic cycle; Cell biology; Endosome; Biology; Batten disease; Neuronal ceroid lipofuscinosis; Autophagy; Function (biology); GTPase-activating protein; Endocytosis; Biochemistry; Receptor; Signal transduction; Intracellular; Gene; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095498,0.0004326218,0.0002447545,0.0002057495,0.0002925634,0.000708914,0.0004150154,0.0004823014,0.000868505],"category_scores_gemma":[0.000242558,0.000126526,0.0003373695,0.0001245099,0.0002831182,0.0004378145,0.0006269762,0.0003001266,0.000390857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001580038,"about_ca_system_score_gemma":0.0004561913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002112189,"about_ca_topic_score_gemma":0.002820698,"domain_scores_codex":[0.9997265,0.0000476386,0.00003331673,0.00006237718,0.00007535701,0.00005474878],"domain_scores_gemma":[0.9998847,0.000009871876,0.0000344517,0.00001517027,0.00002312686,0.00003270072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002692777,0.00001262485,0.001510343,0.00005751982,0.00001584501,0.0001896268,0.00003169469,0.0003330242,0.9942746,0.0007657514,0.0001407429,0.002399002],"study_design_scores_gemma":[0.00004785321,0.0001235363,0.01956416,0.00003147254,0.00003191056,0.0006633529,0.0001224841,0.007610527,0.9634073,0.0004283809,0.007949072,0.00001987849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793404,0.005713243,0.01098593,0.0002695939,0.00005833648,0.00004047345,0.0004151704,0.0001368574,0.003039989],"genre_scores_gemma":[0.9953732,0.0004993638,0.002170847,0.0000812385,0.000004133602,0.00001679833,0.0003465986,0.00001555719,0.001492246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112189,"threshold_uncertainty_score":0.01146406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03196891402720697,"score_gpt":0.3100882142362491,"score_spread":0.2781193002090421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}