{"id":"W3164813515","doi":"10.1093/narcan/zcab019","title":"A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells","year":2021,"lang":"en","type":"article","venue":"NAR Cancer","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Institute for Research in Immunology and Cancer; University of British Columbia; Centre Hospitalier Universitaire de Sherbrooke; Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canadian Association of Gastroenterology; Fonds de Recherche du Québec - Santé; Genome Canada","keywords":"Colorectal cancer; Cancer research; Biology; Cytotoxicity; Kinase; RNA splicing; Regulator; Cell biology; Cancer; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008146353,0.0004030022,0.0003299787,0.0002901628,0.0001207393,0.0001634698,0.00020234,0.0002185038,0.001483038],"category_scores_gemma":[0.00006662859,0.0001094393,0.0002395623,0.0001757158,0.0001227623,0.00008944353,0.0001171187,0.0004195367,0.0004775733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696922,"about_ca_system_score_gemma":0.0001944741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009393172,"about_ca_topic_score_gemma":0.00310132,"domain_scores_codex":[0.9999499,0.000007202144,0.000004207991,0.000009470869,0.00001333797,0.00001592248],"domain_scores_gemma":[0.9999574,0.000007652251,0.000008827718,0.000005308568,0.000007075489,0.0000136866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004362735,0.0001740776,0.0003332894,0.0001294958,0.00002544946,0.0002168192,0.00002950005,0.0003944952,0.980138,0.0002531219,0.0004212131,0.01744819],"study_design_scores_gemma":[0.0005147801,0.005235439,0.006614678,0.00001848933,0.00007186433,0.001392516,0.00003027996,0.001154484,0.9690955,0.00007094625,0.01578457,0.00001641179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852018,0.006706303,0.002559739,0.0001812391,0.00007362946,0.0002047029,0.0006698846,0.0002437741,0.00415901],"genre_scores_gemma":[0.9878101,0.004500146,0.002749267,0.0001039561,0.00002349783,0.0001428485,0.001078467,0.00001983409,0.003571795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001483038,"threshold_uncertainty_score":0.004961193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02082199485125033,"score_gpt":0.2993171186530341,"score_spread":0.2784951238017838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}