{"id":"W3164813515","doi":"10.1093/narcan/zcab019","title":"A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells","year":2021,"lang":"en","type":"article","venue":"NAR Cancer","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Institute for Research in Immunology and Cancer; University of British Columbia; Centre Hospitalier Universitaire de Sherbrooke; Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canadian Association of Gastroenterology; Fonds de Recherche du Québec - Santé; Genome Canada","keywords":"Colorectal cancer; Cancer research; Biology; Cytotoxicity; Kinase; RNA splicing; Regulator; Cell biology; Cancer; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089152,0.0001335069,0.000179453,0.0000341259,0.00007780644,0.00001732878,0.00009082613,0.0001556215,0.00009361493],"category_scores_gemma":[0.00004004878,0.0001211047,0.0000623929,0.00009250492,0.0001021799,0.000004050032,0.00009719956,0.0001514815,0.000001507638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004872032,"about_ca_system_score_gemma":0.0002504361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004506799,"about_ca_topic_score_gemma":0.001045253,"domain_scores_codex":[0.9989931,0.00003799903,0.0001422061,0.0003406777,0.0002135835,0.0002724182],"domain_scores_gemma":[0.9995143,0.00001201143,0.00007508569,0.0001542288,0.0001270642,0.0001173515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126888,0.00008183694,0.006102158,0.00004761452,0.00006344101,0.000007676013,0.00006659026,0.00004080982,0.9915336,0.000006508913,0.001536464,0.0004005665],"study_design_scores_gemma":[0.0007514544,0.0002440386,0.00500887,0.0000573527,0.000008188304,0.000002762971,0.00004734926,0.0001498668,0.9895352,0.000004788958,0.004053929,0.0001362618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976635,0.0012667,0.00002471909,0.0002160652,0.0001138919,0.0001933734,0.0002293286,0.000007081469,0.0002853529],"genre_scores_gemma":[0.9977895,0.0005812881,0.0001182166,0.000205223,0.000197213,0.0000573965,0.00006070569,0.00002085548,0.0009696249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002517466,"threshold_uncertainty_score":0.4938505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02082199485125033,"score_gpt":0.2993171186530341,"score_spread":0.2784951238017838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}