{"id":"W3164821397","doi":"10.1136/annrheumdis-2021-eular.1274","title":"AB0420 CIRCULATING MONOCYTES HAVE DISTINCT PHYSICAL PROPERTIES THAT CORRELATE WITH DISEASE ACTIVITY AND SEVERITY AND PREDICT PROGRESSION IN SYSTEMIC SCLEROSIS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Western University","funders":"","keywords":"Medicine; Immunology; Immune system; Population; Peripheral blood mononuclear cell; Immunophenotyping; CD8; Disease; Antibody; Flow cytometry; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089086,0.0003227148,0.0003104071,0.0008098049,0.0003421649,0.0006470775,0.0002171882,0.0006097976,0.001937714],"category_scores_gemma":[0.0009430808,0.0002410879,0.00015904,0.00045492,0.0002232935,0.0002890214,0.0003034495,0.0003331958,0.0005842007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231106,"about_ca_system_score_gemma":0.00009862898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005852632,"about_ca_topic_score_gemma":0.0006846736,"domain_scores_codex":[0.9997172,0.00007387356,0.00003144675,0.00004264995,0.00008521278,0.00004955078],"domain_scores_gemma":[0.9994789,0.0001092636,0.0001675441,0.00003910112,0.00008209907,0.0001231168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002627108,0.000315355,0.7304826,0.00006758061,0.0001036114,0.000892496,0.000377093,0.0002960633,0.2479739,0.0002245395,0.0003094285,0.01633024],"study_design_scores_gemma":[0.00002988976,0.0004247949,0.9907137,0.000009640436,0.00004200181,0.001727694,0.0002377954,0.0007697454,0.00549999,0.0001923747,0.0003408213,0.00001161586],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992163,0.0002577397,0.0001608274,0.00001843315,0.00000712654,0.000002907345,0.0000458194,0.000005620571,0.0002851904],"genre_scores_gemma":[0.9991998,0.00007029631,0.0001667646,0.00003421257,0.00001961012,0.000008329828,0.0001139986,0.000003404282,0.0003835613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937714,"threshold_uncertainty_score":0.006482303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03988735455282813,"score_gpt":0.2675365143961854,"score_spread":0.2276491598433572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}