{"id":"W3164854901","doi":"10.1038/s41434-021-00261-x","title":"The transformative potential of HSC gene therapy as a genetic medicine","year":2021,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bombardier (Canada)","funders":"","keywords":"Genetic enhancement; Regenerative medicine; Stem cell; Biology; Haematopoiesis; Transplantation; Gene delivery; Cell therapy; Immune system; Commercialization; Genome editing; Hematopoietic stem cell; Transformative learning; Immunology; Viral vector; Gene; Genetics; Medicine; Genome; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005044309,0.000832641,0.001034656,0.001809677,0.0002206333,0.00103923,0.0006427195,0.0009854509,0.002638938],"category_scores_gemma":[0.0004705989,0.0001963398,0.0003199348,0.001829139,0.0005849754,0.00102878,0.0005440527,0.002064044,0.001609923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000662778,"about_ca_system_score_gemma":0.0008330973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010039,"about_ca_topic_score_gemma":0.001725747,"domain_scores_codex":[0.9998894,0.00002011269,0.000009265449,0.00001689438,0.00004941486,0.00001486829],"domain_scores_gemma":[0.9998223,0.0001039197,0.00001547647,0.000006271276,0.00003677779,0.00001522605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008728804,0.00008385655,0.00009490663,0.01006799,0.00004736039,0.0002611009,0.00005794067,0.0005355185,0.005987294,0.01815292,0.03008854,0.9345353],"study_design_scores_gemma":[0.00001455675,0.00005578435,0.0002156082,0.001113411,0.000041099,0.0005773542,0.00002721207,0.00008605708,0.001187408,0.003506619,0.9931624,0.00001256525],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009416412,0.997816,0.0002310109,0.0002052593,0.0002166187,0.000002779895,0.00001314564,0.00000562912,0.001415448],"genre_scores_gemma":[0.000752311,0.9978387,0.0002914611,0.0001581706,0.0001481674,0.000005111031,0.00002428483,0.000001771855,0.0007800359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002638938,"threshold_uncertainty_score":0.008828104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04022389931429499,"score_gpt":0.3657468997380648,"score_spread":0.3255230004237698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}