{"id":"W3164854901","doi":"10.1038/s41434-021-00261-x","title":"The transformative potential of HSC gene therapy as a genetic medicine","year":2021,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bombardier (Canada)","funders":"","keywords":"Genetic enhancement; Regenerative medicine; Stem cell; Biology; Haematopoiesis; Transplantation; Gene delivery; Cell therapy; Immune system; Commercialization; Genome editing; Hematopoietic stem cell; Transformative learning; Immunology; Viral vector; Gene; Genetics; Medicine; Genome; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001020721,0.0008505555,0.001732179,0.0001727713,0.0003261142,0.00005411135,0.001463132,0.0006149973,0.0003867788],"category_scores_gemma":[0.00004156257,0.0005284745,0.001087119,0.0005332413,0.0006423741,0.000005161047,0.000121798,0.0004888921,0.00003947983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005374596,"about_ca_system_score_gemma":0.001265052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004045063,"about_ca_topic_score_gemma":0.00002900569,"domain_scores_codex":[0.9951053,0.00127857,0.001172183,0.0008534855,0.0007991606,0.0007912939],"domain_scores_gemma":[0.9970371,0.0001048267,0.0005303402,0.001713827,0.0004049586,0.0002089131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001047573,0.0001061044,3.160146e-7,0.0002425581,0.001648348,0.00002115353,0.0001551814,0.00001206324,0.06924571,0.000006508012,0.0007518216,0.9267626],"study_design_scores_gemma":[0.001832104,0.00557017,0.000002913299,0.0004705967,0.0001313959,0.0001750223,0.00006267173,0.000002872487,0.1338054,0.00007902682,0.8573461,0.0005216939],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009605053,0.9874424,0.0002348725,0.0002114408,0.0003940937,0.001725568,0.0001117562,0.00002085403,0.0002540166],"genre_scores_gemma":[0.000444465,0.9957867,0.0001569955,0.0003256479,0.001211311,0.0003750759,0.0006769334,0.0001977011,0.0008251868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.926241,"threshold_uncertainty_score":0.9997167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04022389931429499,"score_gpt":0.3657468997380648,"score_spread":0.3255230004237698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}