{"id":"W3164859417","doi":"10.1021/acs.est.1c00975","title":"Cross-Model Comparison of Transcriptomic Dose–Response of Short-Chain Chlorinated Paraffins","year":2021,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"Ministry of Science and Technology of the People's Republic of China; Ministry of Education of the People's Republic of China","keywords":"Chlorinated paraffins; Transcriptome; Pregnane X receptor; Computational biology; Potency; Zebrafish; Biology; Chemistry; Cell biology; Pharmacology; Biochemistry; Nuclear receptor; In vitro; Gene; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007997577,0.0006055287,0.0007068393,0.000604387,0.0003315731,0.0007037648,0.0003932493,0.0005570037,0.003904317],"category_scores_gemma":[0.0007321855,0.0002995715,0.001531456,0.0005391036,0.000411357,0.0003646514,0.0005691175,0.001205631,0.0007740005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006933427,"about_ca_system_score_gemma":0.0007143411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003595924,"about_ca_topic_score_gemma":0.004134932,"domain_scores_codex":[0.9993535,0.00009353898,0.00003576813,0.0002947426,0.0001419905,0.00008054588],"domain_scores_gemma":[0.9995288,0.0001605562,0.00006569675,0.00006327256,0.0001425305,0.00003927806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001417461,0.0001921579,0.01102181,0.0004916896,0.0003317832,0.0001237967,0.0001221839,0.004555338,0.9723797,0.0005286736,0.0008903922,0.007945108],"study_design_scores_gemma":[0.0001465948,0.003896605,0.1886472,0.0001339425,0.001388759,0.000570177,0.0007799601,0.03419967,0.7379647,0.002291222,0.02980981,0.000171438],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.917919,0.003505909,0.03973571,0.0002632834,0.0002876009,0.0004063079,0.0313905,0.0007339794,0.005757681],"genre_scores_gemma":[0.9242589,0.002203872,0.02443202,0.0009237679,0.00004356954,0.001897104,0.03712949,0.0004702035,0.008641078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003904317,"threshold_uncertainty_score":0.01306123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619819570510166,"score_gpt":0.284365062950113,"score_spread":0.2681668672450114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}