{"id":"W3164878646","doi":"10.1016/j.celrep.2021.109162","title":"Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Université du Québec à Trois-Rivières; Division of Molecular and Cellular Biosciences; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Canadian Institutes of Health Research; Canada Foundation for Innovation; Howard Hughes Medical Institute; Institute of Genetics; National Institutes of Health","keywords":"Germline; Biology; MAPK/ERK pathway; Somatic cell; Cell biology; Stem cell; Cell growth; Caenorhabditis elegans; Cellular differentiation; Cell fate determination; Kinase; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330946,0.0001584123,0.0002223547,0.00004090236,0.00004090191,0.00002338165,0.00006632109,0.0001887168,0.00002138656],"category_scores_gemma":[0.00001571772,0.0001766248,0.0000751503,0.00009857168,0.00003284738,0.000008256707,0.00006239054,0.0000917498,0.000002595919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003065572,"about_ca_system_score_gemma":0.0002169507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003559262,"about_ca_topic_score_gemma":0.00007398648,"domain_scores_codex":[0.9986985,0.00005728399,0.0004520595,0.000420482,0.0001716808,0.000199973],"domain_scores_gemma":[0.9989265,0.000007082213,0.0003351065,0.0005368541,0.0001331009,0.00006133941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009969793,0.0002636777,0.00851667,0.000144357,0.000008400793,0.00003189383,0.0003474126,0.001109109,0.9883724,8.176145e-7,0.0005861406,0.0006091427],"study_design_scores_gemma":[0.0002634395,0.00008420775,0.008502037,0.00001383987,0.00002108456,0.00003993481,0.00005711687,0.001262614,0.9884889,0.00005865079,0.001034282,0.0001739118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905433,0.0004706757,0.007408904,0.00005067764,0.0001850557,0.0002577228,0.000005579165,0.00001007046,0.001067984],"genre_scores_gemma":[0.9945446,0.00007261757,0.0005555318,0.00004364261,0.00007943522,0.0000150164,0.0002122864,0.00002702197,0.004449879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006853373,"threshold_uncertainty_score":0.7202551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005776985498128881,"score_gpt":0.2068299924559762,"score_spread":0.2010530069578474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}