{"id":"W3164878646","doi":"10.1016/j.celrep.2021.109162","title":"Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Université du Québec à Trois-Rivières; Division of Molecular and Cellular Biosciences; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Canadian Institutes of Health Research; Canada Foundation for Innovation; Howard Hughes Medical Institute; Institute of Genetics; National Institutes of Health","keywords":"Germline; Biology; MAPK/ERK pathway; Somatic cell; Cell biology; Stem cell; Cell growth; Caenorhabditis elegans; Cellular differentiation; Cell fate determination; Kinase; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006783006,0.0003076474,0.0001549119,0.0003170822,0.0002143477,0.000213678,0.0002455911,0.0002140265,0.0006200892],"category_scores_gemma":[0.00007695602,0.0001517758,0.0002091013,0.00007165286,0.000276866,0.0001845402,0.0003007803,0.0004498196,0.0001819697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671854,"about_ca_system_score_gemma":0.0002568399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132614,"about_ca_topic_score_gemma":0.002466571,"domain_scores_codex":[0.9999229,0.000005230459,0.000007710192,0.00002404414,0.0000241513,0.00001590138],"domain_scores_gemma":[0.9998978,0.00001511671,0.00003118583,0.000009514498,0.00001013946,0.00003621009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000291267,0.00000707473,0.000159866,0.00002747239,0.000001383398,0.00004952955,0.00000866024,0.00005514413,0.9987238,0.00009105656,0.0000180117,0.0008287107],"study_design_scores_gemma":[0.00001792582,0.0001322792,0.01696277,0.00001461651,0.00001465766,0.0002495995,0.00004361763,0.002041089,0.9781713,0.0001584919,0.002177938,0.00001570718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957279,0.0008656351,0.001549101,0.00005653382,0.00001946567,0.00001328549,0.0003275968,0.00008326617,0.001357376],"genre_scores_gemma":[0.9948555,0.0005616986,0.002164457,0.00003809655,0.000004425753,0.00002964988,0.0002148334,0.00003130905,0.002100095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132614,"threshold_uncertainty_score":0.002664089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005776985498128881,"score_gpt":0.2068299924559762,"score_spread":0.2010530069578474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}