{"id":"W3164883358","doi":"10.1182/blood.2021011725","title":"The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute","keywords":"Hemodialysis; Medicine; Heparin; Dialysis; Placebo; Internal medicine; Activated clotting time; Adverse effect; Urology; Surgery; Anesthesia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002577994,0.0001401658,0.0009852061,0.00007858074,0.00006850289,0.00002790149,0.0001121835,0.0001466088,0.00002481693],"category_scores_gemma":[0.01195835,0.00009770395,0.0005342651,0.0003291186,0.0001076314,0.00007605165,0.00005725193,0.000187193,0.000004740522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001935404,"about_ca_system_score_gemma":0.0003563457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585373,"about_ca_topic_score_gemma":0.0001688101,"domain_scores_codex":[0.9971369,0.0004879359,0.001514758,0.0003016862,0.0003582139,0.000200519],"domain_scores_gemma":[0.9957932,0.002868541,0.0004449438,0.0005928401,0.0002065349,0.00009390197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9736456,0.004840971,0.002147755,0.00003362964,0.0007104379,0.00005168555,0.0005740502,0.000002010975,0.004801542,0.0006403065,0.001401297,0.01115078],"study_design_scores_gemma":[0.9384565,0.0004852733,0.004527127,0.0001601133,0.0006263789,0.000007344227,0.000117821,0.0002543518,0.05371144,0.0004969868,0.00105727,0.00009943172],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944922,0.0008665908,0.00003918192,0.001936451,0.0004107204,0.0009880427,0.00001752034,0.00003126921,0.001218067],"genre_scores_gemma":[0.997631,0.000352933,0.0001920839,0.0001384858,0.0009372091,0.00006207896,0.0001025048,0.00001545488,0.0005682892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0489099,"threshold_uncertainty_score":0.9963644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03941692321463643,"score_gpt":0.3465976888030942,"score_spread":0.3071807655884578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}