{"id":"W3164890337","doi":"10.18632/aging.203108","title":"Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Alzheimerfonden; Karolinska Institutet; Vetenskapsrådet; Eisai; Johnson and Johnson Pharmaceutical Research and Development; Stiftelsen Olle Engkvist Byggmästare; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; Janssen Alzheimer Immunotherapy Research And Development; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Demensfonden; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Foundation for the National Institutes of Health","keywords":"Cognitive impairment; Cognition; Psychology; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004890031,0.00009249631,0.0001802053,0.0001182961,0.00005848704,0.00002628511,0.00002318103,0.00003509988,0.0003436506],"category_scores_gemma":[0.0003116356,0.00006991633,0.00004879267,0.0002713401,0.00006665744,0.00008426217,0.00004806571,0.0001687162,0.00001233781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002299382,"about_ca_system_score_gemma":0.0001013569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004508525,"about_ca_topic_score_gemma":0.00003528215,"domain_scores_codex":[0.9988226,0.0001902878,0.0002043632,0.0002171065,0.0003743446,0.0001913095],"domain_scores_gemma":[0.9991585,0.0003716009,0.00006060455,0.0000700295,0.0002884309,0.00005084704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000449332,0.0006120385,0.9217238,0.0001331005,0.0001937021,0.0002210637,0.003172996,9.122218e-8,0.002149747,0.00012447,0.00004379819,0.07117587],"study_design_scores_gemma":[0.002852642,0.0005201955,0.9708413,0.0006321923,0.000309619,0.00006731567,0.01423695,0.00006526261,0.0100327,0.0003478483,0.00002767242,0.00006630674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926104,0.0005315965,0.0005969313,0.0006106433,0.0000447929,0.000576944,0.000005814014,0.00001039383,0.005012504],"genre_scores_gemma":[0.9986072,0.0001677664,0.00001460742,0.0007710113,0.00004652054,0.00006961692,0.0001129912,0.00000794792,0.000202373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07110956,"threshold_uncertainty_score":0.3762733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806110534884012,"score_gpt":0.3254135239272095,"score_spread":0.3073524185783694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}