{"id":"W3164890337","doi":"10.18632/aging.203108","title":"Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Alzheimerfonden; Karolinska Institutet; Vetenskapsrådet; Eisai; Johnson and Johnson Pharmaceutical Research and Development; Stiftelsen Olle Engkvist Byggmästare; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; Janssen Alzheimer Immunotherapy Research And Development; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Demensfonden; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Foundation for the National Institutes of Health","keywords":"Cognitive impairment; Cognition; Psychology; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003011261,0.0006020869,0.0007280667,0.002557234,0.0006404723,0.00160772,0.001050715,0.0007709599,0.001446448],"category_scores_gemma":[0.008841236,0.00038583,0.0006568619,0.001372475,0.0006308219,0.0009669906,0.002192685,0.0007595972,0.0002934976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008358235,"about_ca_system_score_gemma":0.0005857749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01201059,"about_ca_topic_score_gemma":0.01893558,"domain_scores_codex":[0.9984286,0.000362511,0.0001684916,0.0005758618,0.0002389354,0.0002255811],"domain_scores_gemma":[0.9955869,0.0006132085,0.001448104,0.0009458988,0.000647891,0.0007580603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001087083,0.00002990441,0.9960662,0.00001164698,0.0001744691,0.0001552037,0.0003152449,0.00004917584,0.0002906708,0.00006395063,0.0004623881,0.001294148],"study_design_scores_gemma":[0.00002548965,0.00004246317,0.9991871,0.000006808909,0.0000335691,0.0002085943,0.0001825556,0.00007295442,0.00004426497,0.00004274808,0.0001474832,0.000006100772],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977369,0.0002881342,0.00006110394,0.00006842782,0.00001114075,0.0000145566,0.001335196,0.000008532154,0.0004759327],"genre_scores_gemma":[0.9968833,0.00008595849,0.00007443801,0.00006610073,0.00002255567,0.00003232248,0.002505712,0.000009534581,0.0003199602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01201059,"threshold_uncertainty_score":0.02388132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806110534884012,"score_gpt":0.3254135239272095,"score_spread":0.3073524185783694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}