{"id":"W3164906921","doi":"10.1021/acsmedchemlett.1c00196","title":"Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Cancer Institute","keywords":"In vivo; Lactate dehydrogenase; Oxalate; Chemistry; Primary hyperoxaluria; Pharmacology; Biochemistry; Enzyme; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001741473,0.000352069,0.0005426431,0.00003872502,0.0001352212,0.00002451451,0.00009302654,0.0001605038,0.0001323725],"category_scores_gemma":[0.0002300233,0.000309852,0.0002562424,0.0002114919,0.0001421471,0.00008223716,0.00006557188,0.0003032435,0.00002802536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381862,"about_ca_system_score_gemma":0.000358971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001858338,"about_ca_topic_score_gemma":4.763151e-7,"domain_scores_codex":[0.9978604,0.00002497327,0.0004434924,0.0005923602,0.0005099081,0.000568893],"domain_scores_gemma":[0.9985539,0.0001216859,0.0001380012,0.0004830364,0.0001424985,0.0005609082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005433207,0.0002735335,0.004513049,0.0006079461,0.000346934,0.002028961,0.0001919599,0.000001809161,0.9793308,0.000002388869,0.01093648,0.001222815],"study_design_scores_gemma":[0.007763716,0.0001365173,0.004004213,0.0003446809,0.0008369285,0.002437551,0.0002237567,0.00002949986,0.9574963,0.0000245946,0.02634799,0.0003542005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785647,0.0006761397,0.00006535758,0.01888436,0.0002599613,0.00036006,0.00005557252,0.0000964397,0.001037433],"genre_scores_gemma":[0.975898,0.00006423697,0.001562002,0.01861916,0.001296718,0.0001237409,0.0008008349,0.00007750176,0.001557804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02183445,"threshold_uncertainty_score":0.9999353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074232205001401,"score_gpt":0.2493329960057132,"score_spread":0.2385906739556992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}