{"id":"W3164906921","doi":"10.1021/acsmedchemlett.1c00196","title":"Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Cancer Institute","keywords":"In vivo; Lactate dehydrogenase; Oxalate; Chemistry; Primary hyperoxaluria; Pharmacology; Biochemistry; Enzyme; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878713,0.0003408618,0.0004080038,0.0002627358,0.0001289016,0.0004179087,0.0003317647,0.0003148174,0.001202072],"category_scores_gemma":[0.0001179995,0.0001675155,0.0003041235,0.0001884218,0.0001874075,0.0002556528,0.0002520819,0.0007874449,0.0003020091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090852,"about_ca_system_score_gemma":0.0003283134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000467414,"about_ca_topic_score_gemma":0.002202874,"domain_scores_codex":[0.9998788,0.00002122167,0.00001331271,0.00002143865,0.00003059049,0.0000346194],"domain_scores_gemma":[0.9999235,0.00001124477,0.00002230888,0.000007571012,0.00001389553,0.00002148081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006450822,0.0003973152,0.0003917213,0.0002354129,0.000038978,0.0001600805,0.00004498576,0.0008166926,0.9788777,0.0005438818,0.0005837958,0.01726441],"study_design_scores_gemma":[0.0002537189,0.003291845,0.001112429,0.00002219586,0.00005680048,0.0005128421,0.00002290085,0.002270657,0.9815518,0.0001184126,0.01077347,0.00001295395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624928,0.01217469,0.01671829,0.0006833917,0.0001631066,0.0003653936,0.0006649286,0.0003481394,0.006389313],"genre_scores_gemma":[0.9854597,0.003689121,0.00715415,0.0001743363,0.000017535,0.00009370324,0.0003350708,0.00002200053,0.003054352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202072,"threshold_uncertainty_score":0.004021347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074232205001401,"score_gpt":0.2493329960057132,"score_spread":0.2385906739556992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}