{"id":"W3164927366","doi":"10.1073/pnas.2025013118","title":"LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agencia Estatal de Investigación; European Regional Development Fund; Generalitat de Catalunya; Santander Universities; Fundación Botín; Institució Catalana de Recerca i Estudis Avançats; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institute for Research in Biomedicine; Centres de Recerca de Catalunya; Ministerio de Ciencia, Innovación y Universidades; Banco Santander; National Science Foundation","keywords":"Tonicity; Chloride channel; Cell biology; Chemistry; Osmotic shock; Protein kinase A; Kinase; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147183,0.0001991339,0.0002580458,0.0001038934,0.0001852531,0.0003569147,0.0002262311,0.0003779677,0.001874657],"category_scores_gemma":[0.0002048812,0.00008233904,0.000260744,0.00007047355,0.0003463923,0.000440567,0.0003045941,0.0005513826,0.0007189753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136326,"about_ca_system_score_gemma":0.0001831517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002781545,"about_ca_topic_score_gemma":0.000347078,"domain_scores_codex":[0.9997993,0.00002132198,0.00001931232,0.00005418816,0.0000479067,0.00005803548],"domain_scores_gemma":[0.9998295,0.00001174501,0.00006533882,0.00002045296,0.00002254548,0.0000504166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007896926,0.000007129051,0.0002374913,0.00002186269,0.000002285469,0.00006681083,0.000008879044,0.00003095768,0.9987651,0.0001154327,0.00004519638,0.0006199012],"study_design_scores_gemma":[0.00003160255,0.000202744,0.03056377,0.00001472272,0.00001768507,0.001096748,0.0001147364,0.002951202,0.9598483,0.000337522,0.004805976,0.00001492571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915719,0.001509149,0.004133378,0.0004751249,0.00006875987,0.00001858377,0.0002712395,0.0001841161,0.001767584],"genre_scores_gemma":[0.9970957,0.0002838863,0.000924971,0.00006263846,0.00001021925,0.00001450386,0.0001928639,0.000016863,0.001398394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874657,"threshold_uncertainty_score":0.006271362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317104389461293,"score_gpt":0.2807051299389166,"score_spread":0.2489946909927873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}