{"id":"W3164927366","doi":"10.1073/pnas.2025013118","title":"LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agencia Estatal de Investigación; European Regional Development Fund; Generalitat de Catalunya; Santander Universities; Fundación Botín; Institució Catalana de Recerca i Estudis Avançats; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institute for Research in Biomedicine; Centres de Recerca de Catalunya; Ministerio de Ciencia, Innovación y Universidades; Banco Santander; National Science Foundation","keywords":"Tonicity; Chloride channel; Cell biology; Chemistry; Osmotic shock; Protein kinase A; Kinase; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030505,0.00006015253,0.00008628079,0.0000371647,0.0001662123,0.00001391669,0.0001428977,0.00008511422,0.000009701722],"category_scores_gemma":[0.00007627928,0.00004915228,0.0000695139,0.000141341,0.000221592,0.00002305669,0.00003746261,0.00004135813,1.872818e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007160349,"about_ca_system_score_gemma":0.00006307125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002040169,"about_ca_topic_score_gemma":3.182373e-7,"domain_scores_codex":[0.9993007,0.000002359773,0.0001587153,0.0001932404,0.0002470368,0.00009796579],"domain_scores_gemma":[0.9995606,0.00002091685,0.0001406117,0.000006137425,0.0002508597,0.00002086282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005911115,0.00002967617,0.002665548,0.00005057592,0.0000195818,3.183782e-9,0.00006736434,0.0001656509,0.9900863,0.006304431,0.0004953314,0.00005642894],"study_design_scores_gemma":[0.0002756724,0.00008002215,0.02797916,0.00002309383,0.0000131586,0.000003690412,0.0003477877,0.0005045256,0.9508498,0.01924079,0.0006093209,0.00007298103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957095,0.0002179546,0.00002759761,0.002456612,0.00004799811,0.00009044048,0.00005159517,0.000001990783,0.001396346],"genre_scores_gemma":[0.9984092,0.00007804725,0.0002120764,0.0003120873,0.0001614926,0.000009749413,0.000004994848,0.00000374306,0.0008086159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0392365,"threshold_uncertainty_score":0.2004372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317104389461293,"score_gpt":0.2807051299389166,"score_spread":0.2489946909927873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}