{"id":"W3164941196","doi":"10.1136/annrheumdis-2021-eular.896","title":"AB0108 USING RNA SEQUENCING TO IDENTIFY GENE EXPRESSION SIGNATURES ASSOCIATED WITH RESPONSE TO ABATACEPT IN PATIENTS WITH RHEUMATOID ARTHRITIS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Canadian Institutes of Health Research; Regeneron Pharmaceuticals; Gilead Sciences; Sanofi; Amgen; Pfizer; Patient-Centered Outcomes Research Institute; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Abatacept; Medicine; Rheumatoid arthritis; Internal medicine; Biomarker; Immunology; Arthritis; Oncology; Rituximab; Antibody; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320103,0.0001852197,0.0002932294,0.0005226576,0.0001871682,0.0004373032,0.0001122941,0.0002328626,0.001171029],"category_scores_gemma":[0.000383211,0.0001065873,0.0001972029,0.0003715464,0.0001556521,0.00009810764,0.00009590165,0.0002602098,0.0002577168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632177,"about_ca_system_score_gemma":0.0001468313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007320682,"about_ca_topic_score_gemma":0.001369255,"domain_scores_codex":[0.9997713,0.0000533834,0.00001671778,0.00005704537,0.00005772617,0.00004394898],"domain_scores_gemma":[0.9998453,0.0000663992,0.000029572,0.000008602659,0.00003196441,0.00001820954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007944852,0.0003823437,0.4012101,0.0002288658,0.0003229718,0.0008760098,0.0003095347,0.0007404749,0.5136335,0.0001471473,0.001169474,0.0730347],"study_design_scores_gemma":[0.000262981,0.002211941,0.9420249,0.00005276806,0.0003895695,0.001837388,0.0005779929,0.005201125,0.04310124,0.0003100745,0.0040051,0.00002478632],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970447,0.0006918145,0.0005944233,0.0000862935,0.00004079355,0.0000267269,0.0004742999,0.00001984775,0.00102115],"genre_scores_gemma":[0.9962854,0.0002600375,0.001499597,0.0002184969,0.00005228365,0.00006645596,0.0007125337,0.000008010328,0.0008971469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171029,"threshold_uncertainty_score":0.003917456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814833688995802,"score_gpt":0.3007881771137593,"score_spread":0.2726398402238013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}